Cartpt Gene Summary [Rat]
Predicted to enable neuropeptide hormone activity. Involved in several processes, including detection of stimulus involved in sensory perception of pain; regulation of circadian sleep/wake cycle; and regulation of secretion by cell. Located in cytoplasm; extracellular space; and neuronal cell body. Used to study cerebral infarction. Biomarker of amphetamine abuse; cognitive disorder (multiple); morphine dependence; obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in alcohol dependence; alcohol use disorder; and obesity. Orthologous to human CARTPT (CART prepropeptide). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cartpt |
| Official Name | CART prepropeptide [Source:RGD Symbol;Acc:2272] |
| Ensembl ID | ENSRNOG00000017712 |
| Bio databases IDs | |
| Aliases | CART prepropeptide |
| Synonyms | CART, CART prepropeptide |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cartpt often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CART_CTD-like
- protein binding
- neuropeptide hormone
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- depressive disorder
- hypothermia
- diabetes mellitus
- obesity
- weight gain
- alcoholism
- attention deficit hyperactivity disorder
- tremor
- infarction
- oppositional defiant disorder
role in cell
- expression in
- phosphorylation in
- cell viability
- number
- activity
- depolarization
- differentiation
- response
- neurotransmission
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- neurites
- nerve ending
- secretory granules
- perikaryon
- axons
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cartpt gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- signal transduction
- negative regulation of appetite
- cell-cell signaling
- synaptic transmission
- adult feeding behavior
- cellular response to starvation
- positive regulation of MAPK cascade
- negative regulation of bone resorption
- negative regulation of glucagon secretion
- positive regulation of blood pressure
- regulation of insulin secretion
- circadian regulation of gene expression
- neuropeptide signaling pathway
- positive regulation of epinephrine secretion
- positive regulation of transmission of nerve impulse
- cellular glucose homeostasis
- positive regulation of protein kinase activity
- somatostatin secretion
- negative regulation of osteoclast differentiation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- secretory granule
- synapse
Molecular Function
What the gene product does at the molecular level
- protein binding
- neuropeptide hormone activity