Pla2g12b Gene Summary [Rat]
Predicted to enable calcium ion binding activity and phospholipase A2 activity. Predicted to be involved in cholesterol homeostasis and triglyceride homeostasis. Predicted to act upstream of or within low-density lipoprotein particle remodeling. Predicted to be located in extracellular region. Orthologous to human PLA2G12B (phospholipase A2 group XIIB). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pla2g12b |
| Official Name | phospholipase A2, group XIIB [Source:RGD Symbol;Acc:1588484] |
| Ensembl ID | ENSRNOG00000046619 |
| Bio databases IDs | |
| Aliases | phospholipase A2, group XIIB |
| Synonyms | 2010002E04Rik, FKSG71, GXIIB, GXIIIsPLA2, hlb218, phospholipase A2 group XIIB, phospholipase A2, group XIIB, PLA2G13, sPLA2-GXIIB |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pla2g12b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Prokaryotic phospholipase A2
- enzyme
Pathways
Biological processes and signaling networks where the Pla2g12b gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Antioxidant Action of Vitamin C
- Atherosclerosis Signaling
- CCR3 Signaling in Eosinophils
- Docosahexaenoic Acid (DHA) Signaling
- Eicosanoid Signaling
- Endothelin-1 Signaling
- ERK/MAPK Signaling
- Fc Epsilon RI Signaling
- Glucocorticoid Receptor Signaling
- MIF Regulation of Innate Immunity
- MIF-mediated Glucocorticoid Regulation
- Neuroinflammation Signaling Pathway
- p38 MAPK Signaling
- Role of MAPK Signaling in the Pathogenesis of Influenza
- Serotonin Receptor Signaling
- Sperm Motility
- VEGF Family Ligand-Receptor Interactions
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pla2g12b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- arachidonic acid secretion
- lipid catabolic process
- phospholipid metabolic process
- triglyceride homeostasis
- cholesterol homeostasis
Cellular Component
Where in the cell the gene product is active
- extracellular region
Molecular Function
What the gene product does at the molecular level
- phospholipase A2 activity
- calcium ion binding