Adamts1 Gene Summary [Rat]
Predicted to enable heparin binding activity and metalloendopeptidase activity. Involved in several processes, including cellular response to parathyroid hormone stimulus; cellular response to prostaglandin E stimulus; and cellular response to vitamin D. Located in collagen-containing extracellular matrix. Biomarker of brain ischemia; epilepsy; myocardial infarction; transient cerebral ischemia; and ureteral obstruction. Orthologous to human ADAMTS1 (ADAM metallopeptidase with thrombospondin type 1 motif 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adamts1 |
| Official Name | ADAM metallopeptidase with thrombospondin type 1 motif, 1 [Source:RGD Symbol;Acc:621241] |
| Ensembl ID | ENSRNOG00000001607 |
| Bio databases IDs | |
| Aliases | ADAM metallopeptidase with thrombospondin type 1 motif, 1 |
| Synonyms | ADAM metallopeptidase with thrombospondin type 1 motif 1, ADAM metallopeptidase with thrombospondin type 1 motif, 1, ADAMTS, C3-C5, METH-1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Adamts1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Thrombospondin type 1 repeats
- Thrombospondin type 1 domain
- Reprolysin family propeptide
- extracellular domain
- thrombospondin type 1 repeat
- thrombospondin-1 motif
- ADAMTS cysteine-rich domain 2
- ADAMTS cysteine-rich domain
- metalloprotease domain
- peptidase
- protein binding
- zinc binding domain
- disintergrin domain
- metallopeptidase
- ZnMc
- ADAM-TS Spacer 1
- ADAM cysteine-rich
- Metallo-peptidase family M12B Reprolysin-like
- spacer domain
- Reprolysin (M12B) family zinc metalloprotease
- Spondin-like TSP1 domain
- heparin binding
- cysteine rich domain
- metalloendopeptidase
Pathways
Biological processes and signaling networks where the Adamts1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- neoplasia
- osteoarthritis
- epithelial cancer
- cancer
- adenoma formation
- pancreatic cancer
- non-small cell lung cancer
- metastasis
- liver cancer
role in cell
- proliferation
- quantity
- migration
- apoptosis
- activation in
- survival
- invasion by
- formation by
- tubulation by
- shedding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cytoplasmic vesicles
- extracellular matrix
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Adamts1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ovulation from ovarian follicle
- negative regulation of angiogenesis
- integrin-mediated signaling pathway
- positive regulation of G1/S transition of mitotic cell cycle
- kidney development
- negative regulation of cell proliferation
- proteolysis
- extracellular matrix organization
- heart trabecula formation
Cellular Component
Where in the cell the gene product is active
- basement membrane
- cytoplasmic vesicle
- extracellular matrix
- extracellular region
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- heparin binding
- metalloendopeptidase activity
- metallopeptidase activity