Arhgef16 Gene Summary [Rat]
Predicted to enable PDZ domain binding activity; enzyme binding activity; and guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including activation of GTPase activity; cell chemotaxis; and positive regulation of protein localization to plasma membrane. Orthologous to human ARHGEF16 (Rho guanine nucleotide exchange factor 16). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arhgef16 |
| Official Name | Rho guanine nucleotide exchange factor 16 [Source:RGD Symbol;Acc:1588981] |
| Ensembl ID | ENSRNOG00000046803 |
| Bio databases IDs | |
| Aliases | Rho guanine nucleotide exchange factor 16 |
| Synonyms | Ephexin4, GEF16, LOC638799, NBR, Rho guanine nucleotide exchange factor 16 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Arhgef16 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGEF
- receptor tyrosine kinase binding
- guanyl-nucleotide exchange factor
- PH domain
- enzyme binding
- GTPase activator
- protein binding
- Pleckstrin homology-like domain
- Dbl homology domain
- RhoGEF domain
- PDZ-domain binding
- Src Homology 3 domain superfamily
Pathways
Biological processes and signaling networks where the Arhgef16 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Arhgef16 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell chemotaxis
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- cadherin binding
- guanyl-nucleotide exchange factor activity
- PDZ domain binding
- small GTPase binding
- receptor tyrosine kinase binding