Alkbh7 Gene Summary [Rat]
Predicted to be involved in several processes, including fatty acid metabolic process; regulation of lipid storage; and regulation of mitochondrial membrane permeability involved in programmed necrotic cell death. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial matrix. Orthologous to human ALKBH7 (alkB homolog 7). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Alkbh7 |
| Official Name | alkB homolog 7 [Source:RGD Symbol;Acc:1598126] |
| Ensembl ID | ENSRNOG00000047089 |
| Bio databases IDs | |
| Aliases | alkB homolog 7 |
| Synonyms | 2310045B01Rik, 2510008E23Rik, ABH7, alkB homolog 7, LOC681562, SPATA11, UNQ6002 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Alkbh7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- 2OG-Fe(II) oxygenase superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- cutaneous melanoma
- cutaneous melanoma cancer
role in cell
- cell death
- cell viability
- sensitivity
- size
- function
- DNA damage response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Alkbh7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to DNA damage stimulus
- fatty acid metabolic process
- regulation of lipid storage
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- dioxygenase activity
- protein binding
- metal ion binding