Plaat1 Gene Summary [Rat]
Enables phospholipase activity. Predicted to be involved in glycerophospholipid metabolic process; lens fiber cell differentiation; and organelle disassembly. Predicted to act upstream of or within ether lipid metabolic process and peroxisome organization. Predicted to be located in several cellular components, including lysosome; nuclear envelope lumen; and peroxisome. Predicted to be active in cytoplasm. Orthologous to human PLAAT1 (phospholipase A and acyltransferase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Plaat1 |
| Official Name | phospholipase A and acyltransferase 1 [Source:RGD Symbol;Acc:1309485] |
| Ensembl ID | ENSRNOG00000001711 |
| Bio databases IDs | |
| Aliases | phospholipase A and acyltransferase 1 |
| Synonyms | 2810012B06Rik, A-C1, HRASLS, HRASLS1, H-REV107, HRSL1, HSD28, phospholipase A and acyltransferase 1, PLA/AT1, RLP-2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Plaat1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipase A1
- N-acyltransferase
- NlpC/P60 family
- enzyme
- protein binding
- O-acyltransferase
- phospholipase A2
- phospholipase
Pathways
Biological processes and signaling networks where the Plaat1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- weight gain
- liver disease
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- amyotrophic lateral sclerosis
- disorder of lipid metabolism
role in cell
- quantity
- growth
- cell death
- accumulation in
- generation in
- distribution in
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Nucleus
- lysosome
- Endoplasmic Reticulum
- Mitochondria
- cytosol
- perinuclear space
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Plaat1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- N-acylphosphatidylethanolamine metabolic process
- phosphatidylcholine metabolic process
- lipid catabolic process
- lens fiber cell differentiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- mitochondrion
- membrane
- cytosol
- endoplasmic reticulum
- nuclear envelope lumen
- lysosome
Molecular Function
What the gene product does at the molecular level
- phospholipase A2 activity
- 1-acyl-2-lysophosphatidylserine acylhydrolase activity
- protein binding
- O-acyltransferase activity
- phosphatidylserine 1-acylhydrolase activity
- phosphatidylcholine 1-acylhydrolase activity
- N-acyltransferase activity