Mtif3 Gene Summary [Rat]
This gene encodes a translation initiation factor that is involved in mitochondrial protein synthesis. Polymorphism in this gene is associated with the onset of Parkinson's disease. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 5. [provided by RefSeq, Oct 2009]
Details
| Type | Protein Coding |
| Official Symbol | Mtif3 |
| Official Name | mitochondrial translational initiation factor 3 [Source:RGD Symbol;Acc:1592673] |
| Ensembl ID | ENSRNOG00000047329 |
| Bio databases IDs | |
| Aliases | mitochondrial translational initiation factor 3 |
| Synonyms | 2810012L14RIK, IF3mt, mitochondrial translational initiation factor 3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mtif3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nucleic acid binding translation factor
- Translation initiation factor IF-3, C-terminal domain
- Translation initiation factor IF-3, N-terminal domain
- protein binding
- translation initiation factor IF-3
- translation regulator
- ribosomal small subunit binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mtif3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ribosome disassembly
- mitochondrial translational initiation
Cellular Component
Where in the cell the gene product is active
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- translation initiation factor activity
- protein binding
- ribosome binding
- ribosomal small subunit binding
- translation factor activity, nucleic acid binding