Card14 Gene Summary [Rat]
Predicted to enable CARD domain binding activity. Predicted to be involved in several processes, including positive regulation of NF-kappaB transcription factor activity; positive regulation of canonical NF-kappaB signal transduction; and tumor necrosis factor-mediated signaling pathway. Predicted to be located in aggresome and cytosol. Human ortholog(s) of this gene implicated in pityriasis rubra pilaris and psoriasis 2. Orthologous to human CARD14 (caspase recruitment domain family member 14). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Card14 |
| Official Name | caspase recruitment domain family, member 14 [Source:RGD Symbol;Acc:1591135] |
| Ensembl ID | ENSRNOG00000047367 |
| Bio databases IDs | |
| Aliases | caspase recruitment domain family, member 14 |
| Synonyms | BIMP2, CARMA2, caspase recruitment domain family member 14, caspase recruitment domain family, member 14, PRP, PSORS2, PSS1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Card14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CARD domain binding
- Coiled-coil region of CCDC155 or KASH
- Domain present in PSD-95, Dlg, and ZO-1/2
- Tropomyosin like
- Ezrin/radixin/moesin, alpha-helical domain
- Domain of unknown function (DUF4795)
- canonical PDZ domain
- protein binding
- PDZ domain
- Src Homology 3 domain superfamily
- Tropomyosin
- Caspase recruitment domain
- Death Domain Superfamily of protein-protein interaction domains
- Centrosomal protein of 63 kDa
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- seborrheic dermatitis
- dermatological disorder
- salivary gland mucoepidermoid carcinoma
- salivary gland cancer
- epithelial cancer
- psoriasis
- psoriasis type 2
- pityriasis rubra pilaris
- susceptibility to psoriasis 2
- papulosquamous eruption
role in cell
- apoptosis
- activation in
- infiltration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- aggresome
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Card14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tumor necrosis factor-mediated signaling pathway
- negative regulation of apoptotic process
- activation of NF-kappaB-inducing kinase activity
- positive regulation of protein phosphorylation
- apoptotic process
- positive regulation of NF-kappaB transcription factor activity
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- aggresome
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- CARD domain binding