Nrxn3 Gene Summary [Rat]
Predicted to enable calcium channel regulator activity. Predicted to be involved in several processes, including modulation of chemical synaptic transmission; neurotransmitter receptor localization to postsynaptic specialization membrane; and postsynaptic density assembly. Predicted to act upstream of or within neurotransmitter secretion and synapse assembly. Predicted to be located in presynaptic membrane. Predicted to be part of trans-synaptic protein complex. Predicted to be active in GABA-ergic synapse; glutamatergic synapse; and presynaptic active zone membrane. Human ortholog(s) of this gene implicated in alcohol dependence and nicotine dependence. Orthologous to human NRXN3 (neurexin 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Nrxn3 |
| Official Name | neurexin 3 [Source:RGD Symbol;Acc:620212] |
| Ensembl ID | ENSRNOG00000047574 |
| Bio databases IDs | |
| Aliases | neurexin 3 |
| Synonyms | 4933401A11RIK, C14ORF60, LOC100418878, LOC100505240, LOC108351353, neurexin 3, neurexin III, Nrxn3a |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nrxn3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- signaling receptor activity
- LNS repeats
- LamG
- cell adhesion molecule binding
- protein binding
- receptor binding
- calcium channel regulator
- EGF_CA
- Concanavalin A-like lectin/glucanases superfamily
- putative band 4.1 homologues' binding motif
- Syndecan domain
- transmembrane receptor
- laminin G domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- idiopathic pulmonary fibrosis
- obesity
- diabetic retinopathy
- hypertension
- colorectal cancer
- diabetes mellitus
- major depression
- schizophrenia
- acute myeloid leukemia
regulates
- neurotransmitter
- voltage-gated calcium channel
- TAFA1
role in cell
- expression in
- guidance
- formation
- transmission
- cell-cell adhesion
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cell surface
- cellular membrane
- presynaptic membrane
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nrxn3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- social behavior
- signal transduction
- angiogenesis
- neuron cell-cell adhesion
- axon guidance
- learning
- adult behavior
- vocalization behavior
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- cell projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- transmembrane signaling receptor activity
- metal ion binding
- signaling receptor activity
- cell adhesion molecule binding
- neuroligin family protein binding