Zic2 Gene Summary [Rat]
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin DNA binding activity. Predicted to be involved in several processes, including nervous system development; regulation of DNA-templated transcription; and visual perception. Predicted to act upstream of or within several processes, including neural crest cell differentiation; neural tube closure; and nodal signaling pathway. Predicted to be located in cytoplasm and nuclear body. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in holoprosencephaly and holoprosencephaly 5. Orthologous to human ZIC2 (Zic family member 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zic2 |
| Official Name | Zic family member 2 [Source:RGD Symbol;Acc:1311174] |
| Ensembl ID | ENSRNOG00000054879 |
| Bio databases IDs | |
| Aliases | Zic family member 2 |
| Synonyms | HPE5, KU, Zic family member 2, zinc finger protein of the cerebellum 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Zic2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- Zic Opa-conserved domain
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- nucleic acid binding
- chromatin binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- zinc finger
- double-stranded DNA binding
- Zinc-finger double domain
- zinc finger domain
- Zic proteins zinc finger domain
- transcription factor activity
Pathways
Biological processes and signaling networks where the Zic2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- rectum cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- colon adenocarcinoma
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- nasopharyngeal carcinoma
- nasopharyngeal cancer
role in cell
- expression in
- proliferation
- growth
- colony formation by
- sphere formation by
- differentiation
- accumulation
- M2 polarization
- migration
- sphere-forming capacity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Zic2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- central nervous system development
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- cell differentiation
- brain development
- visual perception
- positive regulation of sequence-specific DNA binding transcription factor activity
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- chromatin DNA binding
- sequence-specific DNA binding transcription factor activity
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity