Trip6 Gene Summary [Rat]
Predicted to enable interleukin-1 receptor binding activity and kinase binding activity. Predicted to be involved in several processes, including chordate embryonic development; positive regulation of cell migration; and positive regulation of non-canonical NF-kappaB signal transduction. Predicted to be located in several cellular components, including cytoskeleton; cytosol; and nucleus. Predicted to be active in cytoplasm; focal adhesion; and stress fiber. Orthologous to human TRIP6 (thyroid hormone receptor interactor 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Trip6 |
| Official Name | thyroid hormone receptor interactor 6 [Source:RGD Symbol;Acc:1583180] |
| Ensembl ID | ENSRNOG00000048580 |
| Bio databases IDs | |
| Aliases | thyroid hormone receptor interactor 6 |
| Synonyms | OIP-1, thyroid hormone receptor interactor 6, TRIP6i2, ZRP, ZRP-1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Trip6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- interleukin-1 receptor binding
- nuclear export signal
- kinase binding
- LIM is a small protein-protein interaction domain, containing two zinc fingers
- protein binding
- cytokine
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- tumorigenesis
- gastroesophageal reflux
- hydrocephalus
role in cell
- phosphorylation in
- binding in
- cell death
- number
- migration
- length
- mislocalization
- morphogenesis in
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cytoskeleton
- focal adhesions
- Nucleus
- Plasma Membrane
- cytosol
- growth cone
- neurites
- actin stress fibers
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Trip6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chordate embryonic development
- signal transduction
- focal adhesion assembly
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoskeleton
- focal adhesion
- cytoplasm
- stress fiber
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- metal ion binding
- kinase binding
- interleukin-1 receptor binding
- thyroid hormone receptor binding