TRIP6 Gene Summary [Human]
This gene is a member of the zyxin family and encodes a protein with three LIM zinc-binding domains. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane occurs in a lysophosphatidic acid (LPA)-dependent manner and it regulates LPA-induced cell migration. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
Details
| Type | Retained Intron |
| Official Symbol | TRIP6 |
| Official Name | thyroid hormone receptor interactor 6 [Source:HGNC Symbol;Acc:HGNC:12311] |
| Ensembl ID | ENSG00000087077 |
| Bio databases IDs | |
| Aliases | thyroid hormone receptor interactor 6 |
| Synonyms | OIP-1, thyroid hormone receptor interactor 6, TRIP6i2, ZRP, ZRP-1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRIP6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- interleukin-1 receptor binding
- nuclear export signal
- kinase binding
- LIM is a small protein-protein interaction domain, containing two zinc fingers
- protein binding
- cytokine
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- tumorigenesis
- gastroesophageal reflux
- hydrocephalus
role in cell
- phosphorylation in
- binding in
- cell death
- number
- migration
- length
- mislocalization
- morphogenesis in
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cytoskeleton
- focal adhesions
- Nucleus
- Plasma Membrane
- cytosol
- growth cone
- neurites
- actin stress fibers
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TRIP6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chordate embryonic development
- signal transduction
- focal adhesion assembly
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoskeleton
- focal adhesion
- cytoplasm
- stress fiber
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- metal ion binding
- kinase binding
- interleukin-1 receptor binding
- thyroid hormone receptor binding