Pdxk Gene Summary [Rat]
Enables pyridoxal binding activity and pyridoxal kinase activity. Involved in several processes, including pyridoxal phosphate biosynthetic process; response to X-ray; and response to progesterone. Predicted to be active in cytosol. Orthologous to human PDXK (pyridoxal kinase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pdxk |
| Official Name | pyridoxal kinase [Source:RGD Symbol;Acc:621324] |
| Ensembl ID | ENSRNOG00000049937 |
| Bio databases IDs | |
| Aliases | pyridoxal kinase |
| Synonyms | 2310036D04RIK, C21ORF124, C21ORF97, HEL-S-1a, HMSN6C, LOC100909742, PKH, PNK, PRED79, Pyridoxal kinase, pyridoxal (pyridoxine, vitamin B6) kinase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pdxk often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- vitamin binding
- ATP binding
- metal ion binding
- magnesium ion binding
- pfkB family carbohydrate kinase
- kinase
- ribokinase_pfkB_like
- pyridoxal phosphate binding
- pyridoxal kinase
- binding protein
- zinc ion binding
- alcohol group acceptor phosphotransferase
- protein homodimerization
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- diabetic nephropathy
- type VIC hereditary motor and sensory neuropathy with optic atrophy
- Down syndrome
- breast carcinoma
- androgenic alopecia
- uterine serous papillary cancer
- severe acute respiratory syndrome
regulates
- pyridoxamine
- pyridoxal phosphate
- pyridoxal
- pyridoxine
role in cell
- proliferation
- cell viability
- migration
- apoptosis
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- secretory granule lumen
- Extracellular Space
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pdxk gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- pyridoxal metabolic process
- pyridoxamine metabolic process
- pyridoxal 5'-phosphate salvage
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- specific granule lumen
- cytosol
- secretory granule lumen
- extracellular region
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ATP binding
- pyridoxal phosphate binding
- zinc ion binding
- protein homodimerization activity
- potassium ion binding
- pyridoxal kinase activity
- sodium ion binding
- lithium ion binding