Eif2b1 Gene Summary [Rat]
Enables GDP binding activity; GTP binding activity; and translation initiation factor activity. Contributes to guanyl-nucleotide exchange factor activity. Involved in several processes, including negative regulation of guanyl-nucleotide exchange factor activity; response to amino acid starvation; and response to glucose. Part of eukaryotic translation initiation factor 2 complex and eukaryotic translation initiation factor 2B complex. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter 1. Orthologous to human EIF2B1 (eukaryotic translation initiation factor 2B subunit alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Eif2b1 |
| Official Name | eukaryotic translation initiation factor 2B subunit alpha [Source:RGD Symbol;Acc:620819] |
| Ensembl ID | ENSRNOG00000001039 |
| Bio databases IDs | |
| Aliases | eukaryotic translation initiation factor 2B subunit alpha |
| Synonyms | D5Ertd406e, eIF-2a, EIF2B, EIF2BA, EIF2Balpha, eukaryotic translation initiation factor 2B subunit alpha, eukaryotic translation initiation factor 2B, subunit alpha, eukaryotic translation initiation factor 2B subunit α, eukaryotic translation initiation factor 2B, subunit α, VWM1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Eif2b1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTP binding
- ribose 1,5-bisphosphate isomerase
- GDP binding
- guanyl-nucleotide exchange factor
- Initiation factor 2 subunit family
- translation initiation factor
- protein binding
- identical protein binding
- translation regulator
Pathways
Biological processes and signaling networks where the Eif2b1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- leukoencephalopathy with vanishing white matter type 1
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
- leukoencephalopathy with vanishing white matter
role in cell
- expression in
- autophagy by
- cell death
- growth
- development
- synthesis in
- survival
- biogenesis
- biogenesis in
- translation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Plasma Membrane
- cytosol
- sensory axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Eif2b1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- oligodendrocyte development
- response to heat
- response to glucose stimulus
- cytoplasmic translational initiation
- translational initiation
- response to peptide hormone stimulus
- T cell receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- membrane
- cytosol
- eukaryotic translation initiation factor 2B complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- translation initiation factor activity
- identical protein binding
- protein binding
- guanyl-nucleotide exchange factor activity