Rbp3 Gene Summary [Rat]
Enables retinol binding activity. Predicted to be involved in eye photoreceptor cell development and retinoid metabolic process. Located in interphotoreceptor matrix. Human ortholog(s) of this gene implicated in retinitis pigmentosa 66. Orthologous to human RBP3 (retinol binding protein 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rbp3 |
| Official Name | retinol binding protein 3 [Source:RGD Symbol;Acc:3545] |
| Ensembl ID | ENSRNOG00000051911 |
| Bio databases IDs | |
| Aliases | retinol binding protein 3 |
| Synonyms | D10S64, D10S65, D10S66, IRBP, RBPI, retinol binding protein 3, retinol binding protein 3, interstitial, RP66 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rbp3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- N-terminal domain of Peptidase_S41 in eukaryotic IRBP
- C-terminal processing peptidase family S41
- retinol binding
- Peptidase family S41
- protein binding
- retinoid binding
- transporter
Pathways
Biological processes and signaling networks where the Rbp3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- retinitis pigmentosa type 66
- retinal dystrophy
- experimental autoimmune uveitis
- systemic lupus erythematosus
- experimental autoimmune uveoretinitis
- Kawasaki disease
- retinitis pigmentosa
- congenital stationary night blindness
- cone-rod dystrophy
- autosomal recessive retinitis pigmentosa
role in cell
- expression in
- apoptosis
- degeneration
- production in
- cellular infiltration by
- number
- quantity
- morphology
- proliferation
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Golgi Apparatus
- Endoplasmic Reticulum
- interphotoreceptor matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rbp3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- retinoid metabolic process
- lipid metabolic process
- proteolysis
- visual perception
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- serine-type peptidase activity
- retinal binding
- retinol binding
- retinoid binding