Epg5 Gene Summary [Rat]
Predicted to be involved in several processes, including autophagosome maturation; cellular response to dsDNA; and endosome to lysosome transport. Predicted to act upstream of with a positive effect on toll-like receptor 9 signaling pathway. Predicted to act upstream of or within several processes, including defense response to other organism; homeostasis of number of retina cells; and host-mediated regulation of intestinal microbiota composition. Predicted to be located in lysosome and perinuclear region of cytoplasm. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Vici syndrome. Orthologous to human EPG5 (ectopic P-granules 5 autophagy tethering factor). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Epg5 |
| Official Name | ectopic P-granules autophagy protein 5 homolog [Source:RGD Symbol;Acc:1306286] |
| Ensembl ID | ENSRNOG00000052894 |
| Bio databases IDs | |
| Aliases | ectopic P-granules autophagy protein 5 homolog |
| Synonyms | 4732475F16, 5430411K18Rik, AC126553.1, BAB14689.1, ectopic P-granules 5 autophagy tethering factor, EG664910, FLJ13755, HEEW1, KIAA1632, RGD1306286, VICIS |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Epg5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
Pathways
Biological processes and signaling networks where the Epg5 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Vici syndrome
- coronary artery disease
- focal cortical dysplasia of Taylor
- centronuclear myopathy
- hereditary disorder
- syndromic retinitis pigmentosa
- growth failure
- kyphosis
- motor dysfunction or movement disorder
- gastric carcinoma
regulates
role in cell
- size
- fusion
- formation
- abnormal morphology
- differentiation
- assembly
- maturation
- apoptosis
- degeneration
- autophagy
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- lysosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Epg5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- toll-like receptor 9 signaling pathway
- endosome to lysosome transport
- endocytic recycling
- nucleotide transport
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- cytoplasm
- lysosome
Molecular Function
What the gene product does at the molecular level
- protein binding