Map1lc3a Gene Summary [Rat]
Predicted to enable microtubule binding activity; phosphatidylethanolamine binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including cellular response to hydrogen peroxide; cellular response to oxygen-glucose deprivation; and intracellular signaling cassette. Located in autophagosome membrane and late endosome. Is active in glutamatergic synapse. Biomarker of several diseases, including artery disease (multiple); degenerative disc disease; ischemia (multiple); retinal detachment; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in glioblastoma. Orthologous to human MAP1LC3A (microtubule associated protein 1 light chain 3 alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Map1lc3a |
| Official Name | microtubule-associated protein 1 light chain 3 alpha [Source:RGD Symbol;Acc:735183] |
| Ensembl ID | ENSRNOG00000025443 |
| Bio databases IDs | |
| Aliases | microtubule-associated protein 1 light chain 3 alpha |
| Synonyms | 1010001H21Rik, 4922501H04Rik, ATG8E, LC3, LC3A, LC3-I, LC3-II, MAP1ALC3, MAP1BLC3, MAP LC3, microtubule-associated protein 1 light chain 3 alpha, microtubule-associated protein 1 light chain 3 α |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Map1lc3a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid binding
- microtubule binding
- ubiquitin protein ligase binding
- Ubl1_cv_Nsp3_N-like
- alpha helix
- protein binding
Pathways
Biological processes and signaling networks where the Map1lc3a gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- osteoarthritis
role in cell
- size
- quantity
- apoptosis
- accumulation in
- growth
- replication in
- production in
- response
- degradation in
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- soluble fraction
- glutaminergic synapse
- microtubule cytoskeleton
- double-membrane vesicle
- intracellular membrane-bounded organelle
- cellular membrane
- cytosol
- synapse
- autophagic vacuoles
- late endosomes
- autolysosomes
- autophagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Map1lc3a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- p38MAPK cascade
- cellular response to amino acid starvation
- response to iron(II) ion
- SMAD protein signal transduction
- JNK cascade
- cellular response to starvation
- cellular response to copper ion
- mitochondrion degradation
- cellular response to nitrogen starvation
- autophagic vacuole assembly
- cellular response to hydrogen peroxide
- response to lead ion
- macroautophagy
Cellular Component
Where in the cell the gene product is active
- intracellular membrane-bounded organelle
- late endosome
- cytosol
- organelle membrane
- autophagic vacuole
- autophagic vacuole membrane
- microtubule
Molecular Function
What the gene product does at the molecular level
- phosphatidylethanolamine binding
- ubiquitin protein ligase binding
- protein binding
- phospholipid binding
- microtubule binding