Vamp8 Gene Summary [Rat]
Enables SNAP receptor activity and syntaxin binding activity. Involved in protein-containing complex assembly and vesicle fusion. Located in endosome; lysosomal membrane; and midbody. Part of SNARE complex. Orthologous to human VAMP8 (vesicle associated membrane protein 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vamp8 |
| Official Name | vesicle-associated membrane protein 8 [Source:RGD Symbol;Acc:620421] |
| Ensembl ID | ENSRNOG00000012748 |
| Bio databases IDs | |
| Aliases | vesicle-associated membrane protein 8 |
| Synonyms | EDB, endobrevin, vesicle-associated membrane protein 8 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Vamp8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SNAP receptor
- cytoplasmic domain
- transmembrane domain
- coiled-coil domain
- protein binding
- SNARE motif
- chloride channel inhibitor activity
- transporter
- syntaxin binding
Pathways
Biological processes and signaling networks where the Vamp8 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- prostate cancer
- epithelial cancer
- prostatic carcinoma
- coronary artery disease
- uterine serous papillary cancer
- hydronephrosis
- glioma
- glioma formation
- Duchenne muscular dystrophy
role in cell
- expression in
- activity
- degranulation
- proliferation
- degradation in
- growth
- formation
- entrance
- morphology
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- endocytic vesicle membrane
- cell center
- Cytoplasm
- cell surface
- apical compartment
- basal compartment
- perinuclear region
- basolateral cell compartment
- cellular membrane
- endosomes
- vesicles
- lysosome
- midbody
- secretory granule membrane
- granules
- tertiary granule membrane
- specific granule membrane
- cytosol
- vesicle membrane
- basolateral membrane
- lysosome membrane
- endosomal membrane
- zymogen granules
- recycling endosomes
- early endosomes
- perinuclear vesicles
- secretory granules
- microsomal membrane
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Vamp8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- eosinophil degranulation
- mucus secretion
- vesicle fusion
- SNARE complex assembly
- autophagic vacuole docking
- protein transport
- defense response to virus
- neutrophil degranulation
Cellular Component
Where in the cell the gene product is active
- lysosomal membrane
- plasma membrane
- zymogen granule membrane
- early endosome membrane
- secretory granule membrane
- late endosome membrane
- early endosome
- perinuclear region of cytoplasm
- extracellular vesicular exosome
- clathrin-coated endocytic vesicle membrane
- cytoplasm
- membrane
- vesicle
- cytosol
- SNARE complex
- phagocytic vesicle membrane
- recycling endosome
- recycling endosome membrane
- azurophil granule membrane
- tertiary granule membrane
- specific granule membrane
Molecular Function
What the gene product does at the molecular level
- chloride channel inhibitor activity
- protein binding
- syntaxin binding
- SNAP receptor activity