Usp8 Gene Summary [Rat]
Predicted to enable K48-linked deubiquitinase activity; K63-linked deubiquitinase activity; and cysteine-type deubiquitinase activity. Involved in cellular response to dexamethasone stimulus; cellular response to nerve growth factor stimulus; and regulation of protein catabolic process at postsynapse, modulating synaptic transmission. Located in early endosome. Is active in glutamatergic synapse and postsynaptic density. Human ortholog(s) of this gene implicated in ACTH-secreting pituitary adenoma. Orthologous to human USP8 (ubiquitin specific peptidase 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Usp8 |
| Official Name | ubiquitin specific peptidase 8 [Source:RGD Symbol;Acc:1304979] |
| Ensembl ID | ENSRNOG00000010729 |
| Bio databases IDs | |
| Aliases | ubiquitin specific peptidase 8 |
| Synonyms | HumORF8, mKIAA0055, PITA4, SPG59, ubiquitin specific peptidase 8, UBPY |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Usp8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- catalytic domain
- Rhodanese Homology Domain
- peptidase
- MIT domain
- USP domain
- protein binding
- Rhodanese-like domain
- RHOD
- Peptidase_C19
- Sh3 domain binding motif
- cysteine endopeptidase
- MAP7 (E-MAP-115) family
- Chromatin assembly factor 1 complex p150 subunit, N-terminal
- Ubiquitin carboxyl-terminal hydrolase
- ubiquitin-specific protease
- USP8 dimerization domain
- ubiquitin-like-specific protease
Pathways
Biological processes and signaling networks where the Usp8 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- adenoma formation
- liver cancer
- epithelial cancer
- neoplasia
- organismal death
- breast cancer
- ACTH-secreting pituitary adenoma type 4
- head and neck neuroendocrine neoplasia
- tumorigenesis
role in cell
- expression in
- accumulation in
- number
- proliferation
- apoptosis
- cell viability
- formation
- formation in
- activation
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- synapto-dendritic compartment
- intracellular space
- perinuclear region
- Plasma Membrane
- vesicles
- Golgi Apparatus
- midbody
- granules
- cytosol
- endosomal membrane
- acrosome
- dendritic spines
- early endosomes
- perikaryon
- postsynaptic density
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Usp8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein deubiquitination
- regulation of protein stability
- endosome organization
- regulation of protein localization
- cytokinesis after mitosis
- proteolysis
- positive regulation of canonical Wnt receptor signaling pathway
- Ras protein signal transduction
- cellular response to dexamethasone stimulus
- protein K63-linked deubiquitination
- protein K48-linked deubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- postsynaptic density
- early endosome
- cytoplasm
- dendritic spine
- cytosol
- endosome membrane
- midbody
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- protein binding
- cadherin binding
- cysteine-type endopeptidase activity
- SH3 domain binding