Scn1a Gene Summary [Rat]
Enables voltage-gated sodium channel activity. Involved in neuronal action potential. Is active in presynaptic membrane. Human ortholog(s) of this gene implicated in Dravet syndrome; developmental and epileptic encephalopathy 6B; familial hemiplegic migraine 3; generalized epilepsy with febrile seizures plus; and generalized epilepsy with febrile seizures plus 2. Orthologous to human SCN1A (sodium voltage-gated channel alpha subunit 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Scn1a |
| Official Name | sodium voltage-gated channel alpha subunit 1 [Source:RGD Symbol;Acc:69364] |
| Ensembl ID | ENSRNOG00000053122 |
| Bio databases IDs | |
| Aliases | sodium voltage-gated channel alpha subunit 1 |
| Synonyms | B230332M13, DEE6, DEE6A, DEE6B, DRVT, EIEE6, FEB3, FEB3A, FHM3, GEFSP2, HBSCI, LOC102553713, NAC1, Nav1.1, SCN1, SMEI, sodium channel, voltage-gated, type I, alpha, sodium channel, voltage-gated, type I, α, Sodium channel α-1 subunit, sodium voltage-gated channel alpha subunit 1, sodium voltage-gated channel α subunit 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Scn1a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sodium ion transport-associated
- Voltage-dependent L-type calcium channel, IQ-associated
- voltage-gated sodium channel
- Cytoplasmic domain of voltage-gated Na+ ion channel
- Ion transport protein
- metal ion binding
- pore domain
- voltage-gated ion channel
- ion channel
- Polycystin cation channel
Pathways
Biological processes and signaling networks where the Scn1a gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- diabetic nephropathy
- infection
- hypertension
- cancer
- pain
- constipation
- Huntington disease
- postoperative pain
- localization-related epilepsy
role in cell
- transmembrane potential
- action potential
- abnormal morphology
- neurotransmission in
- neurotransmission
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent-soluble membrane fractions
- membrane fraction
- axon component
- axon initial segment like process
- outer membranes
- cellular membrane
- intercellular junctions
- presynaptic membrane
- nucleoplasm
- nuclear bodies
- nodes of Ranvier
- synaptic vesicles
- axon initial segments
- Z line
- transverse tubules
- perikaryon
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Scn1a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cardiac muscle cell action potential involved in contraction
- determination of adult lifespan
- nerve development
- neuromuscular process controlling posture
- adult walking behavior
- sodium ion transport
- sodium ion transmembrane transport
- detection of mechanical stimulus involved in sensory perception of pain
- establishment of localization in cell
- neuronal action potential propagation
- membrane depolarization involved in regulation of action potential
- regulation of action potential in neuron
Cellular Component
Where in the cell the gene product is active
- Z disc
- T-tubule
- initial segment
- nuclear body
- voltage-gated sodium channel complex
- node of Ranvier
- intercalated disc
- neuronal cell body
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- voltage-gated sodium channel activity