Cdk7 Gene Summary [Rat]
Enables cyclin-dependent protein serine/threonine kinase activity. Involved in protein phosphorylation and transcription by RNA polymerase II. Part of transcription factor TFIIH holo complex. Orthologous to human CDK7 (cyclin dependent kinase 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cdk7 |
| Official Name | cyclin-dependent kinase 7 [Source:RGD Symbol;Acc:621124] |
| Ensembl ID | ENSRNOG00000018510 |
| Bio databases IDs | |
| Aliases | cyclin-dependent kinase 7 |
| Synonyms | C230069N13, CAK, CAK1, CDKN7, Crk4, cyclin-dependent kinase 7, HCAK, MO15, P39 Mo15, STK1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cdk7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cyclin-dependent protein kinase
- [RNA-polymerase]-subunit kinase
- protein serine/threonine kinase
- protein kinase
- Kinase regulatory loop binding domain
- protein binding
- DNA dependent ATPase
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- ATP-binding pocket
- kinase domain
- binding protein
- Protein Kinases, catalytic domain
- alcohol group acceptor phosphotransferase
Pathways
Biological processes and signaling networks where the Cdk7 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Adipogenesis pathway
- Androgen Signaling
- Assembly of RNA Polymerase II Complex
- Cell Cycle Control of Chromosomal Replication
- Cell Cycle: G2/M DNA Damage Checkpoint Regulation
- Cyclins and Cell Cycle Regulation
- DNA Methylation and Transcriptional Repression Signaling
- Glucocorticoid Receptor Signaling
- Molecular Mechanisms of Cancer
- NER Pathway
- RAR Activation
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- ovarian cancer
- osteosarcoma
- osteosarcomagenesis
- colon cancer
- severe acute respiratory syndrome
role in cell
- expression in
- activation in
- proliferation
- growth
- migration
- phosphorylation in
- cell death
- survival
- cell cycle progression
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- fibrillar center
- Cytoplasm
- Plasma Membrane
- cytosol
- nucleoplasm
- germinal vesicles
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cdk7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- DNA repair
- transcription from RNA polymerase II promoter
- regulation of G1/S transition of mitotic cell cycle
- snRNA transcription from RNA polymerase II promoter
- regulation of cell cycle
- protein stabilization
- positive regulation of transcription from RNA polymerase II promoter
- protein phosphorylation
- transcription initiation from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- cyclin-dependent protein kinase holoenzyme complex
- core TFIIH complex
- holo TFIIH complex
- plasma membrane
- fibrillar center
- nucleoplasm
- male germ cell nucleus
- nucleus
- perinuclear region of cytoplasm
- cytoplasm
- cytosol
- TFIIK complex
- CAK-ERCC2 complex
Molecular Function
What the gene product does at the molecular level
- ATP binding
- DNA-dependent ATPase activity
- protein binding
- RNA polymerase II carboxy-terminal domain kinase activity
- protein kinase activity
- cyclin-dependent protein kinase activity
- protein serine/threonine kinase activity