Aqp6 Gene Summary [Rat]

The protein encoded by this gene is an aquaporin protein, which functions as a water channel in cells. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). This protein is specific for the kidney. This gene and related family members AQP0, AQP2, and AQP5 reside in a cluster on chromosome 12q13. [provided by RefSeq, Jul 2008]

Details

Type
Protein Coding
Official Symbol
Aqp6
Official Name
aquaporin 6 [Source:RGD Symbol;Acc:71100]
Ensembl ID
ENSRNOG00000053181
Bio databases IDs NCBI: 29170 Ensembl: ENSRNOG00000053181
Aliases aquaporin 6
Synonyms AI790337, AQP2L, Aquaporin-2-like, aquaporin 6, KID
Species
Rat, Rattus norvegicus
OrthologiesHumanMouse

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Aqp6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • nitrate transporter
  • anion channel
  • MIP
  • chloride channel
  • ligand-gated ion channel
  • protein binding
  • water channel
  • ammonium transporter
  • transporter

Pathways

Biological processes and signaling networks where the Aqp6 gene in rat plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
regulated by
  • paclitaxel
  • U0126
regulates
  • nitrate
  • water

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • membrane fraction
  • cytoplasmic vesicle membrane
  • intracellular membranes
  • cellular membrane
  • Plasma Membrane
  • vesicles
  • pedicels
  • Golgi cisternae
  • perikaryon
  • vesicle fraction

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the rat Aqp6 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • water transport
  • carbon dioxide transport
  • nitrate transport
  • renal water transport
  • odontogenesis

Cellular Component

Where in the cell the gene product is active
  • cytoplasmic vesicle membrane
  • apical plasma membrane
  • plasma membrane

Molecular Function

What the gene product does at the molecular level
  • nitrate transmembrane transporter activity
  • protein binding
  • water channel activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.