C1galt1 Gene Summary [Rat]
Predicted to enable glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity. Predicted to be involved in kidney development. Predicted to act upstream of or within angiogenesis; intestinal epithelial cell development; and protein O-linked glycosylation. Predicted to be located in membrane. Orthologous to human C1GALT1 (core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | C1galt1 |
| Official Name | core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1 [Source:RGD Symbol;Acc:621105] |
| Ensembl ID | ENSRNOG00000007804 |
| Bio databases IDs | |
| Aliases | core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1 |
| Synonyms | 2210410E06RIK, AV284120, C1GALT, core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1, core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1, core 1 synthase, glycoprotein-N-acetylgalactosamine 3-β-galactosyltransferase 1, core 1 synthase, glycoprotein-N-acetylgalactosamine 3-β-galactosyltransferase, 1, T-syn, T-synthase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat C1galt1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- stem region
- CBRT domain
- catalytic domain
- galactosyltransferase
- enzyme
- protein binding
- glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- progressive vision loss
- COVID-19
- gastric epithelial cancer
- breast cancer
- kidney disease
- organismal death
- lung adenocarcinoma
- lung adenocarcinoma formation
- metastasis
role in cell
- proliferation
- expression in
- apoptosis
- phosphorylation in
- activation in
- cell viability
- migration
- binding
- quantity
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat C1galt1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein O-linked glycosylation
- angiogenesis
- kidney development
- intestinal epithelial cell development
- O-glycan processing, core 1
Cellular Component
Where in the cell the gene product is active
- membrane
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- nucleotide binding
- protein binding
- metal ion binding
- glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity