Soat2 Gene Summary [Rat]
Enables sterol O-acyltransferase activity. Involved in cholesterol metabolic process and response to nutrient. Predicted to be located in brush border; endoplasmic reticulum; and membrane. Predicted to be active in endoplasmic reticulum membrane. Used to study end stage renal disease. Biomarker of nephrotic syndrome. Human ortholog(s) of this gene implicated in coronary artery disease and hepatocellular carcinoma. Orthologous to human SOAT2 (sterol O-acyltransferase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Soat2 |
| Official Name | sterol O-acyltransferase 2 [Source:RGD Symbol;Acc:628865] |
| Ensembl ID | ENSRNOG00000053769 |
| Bio databases IDs | |
| Aliases | sterol O-acyltransferase 2 |
| Synonyms | ACACT2, ACAT2, ARGP2, D15Wsu97e, STEROL O-ACYLTRANSFERASE 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Soat2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- sterol O-acyltransferase
- cholesterol binding
- acyl-CoA binding
- MBOAT, membrane-bound O-acyltransferase family
- enzyme
- protein binding
- transferase, transferring acyl groups
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatic steatosis
- hepatocellular carcinoma
- diabetes mellitus
- experimental autoimmune encephalomyelitis
- atherosclerosis
- epithelial cancer
- liver cancer
- hepatitis B virus-related hepatocellular carcinoma
- hypercholesterolemia
- familial obesity
role in cell
- differentiation
- metabolism in
- generation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- nuclear envelope
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Soat2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- low-density lipoprotein particle clearance
- cholesterol storage
- cholesterol metabolic process
- very-low-density lipoprotein particle assembly
- macrophage derived foam cell differentiation
- cholesterol efflux
- intestinal cholesterol absorption
- cholesterol homeostasis
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- brush border
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- transferase activity, transferring acyl groups
- protein binding
- cholesterol binding
- fatty-acyl-CoA binding
- cholesterol O-acyltransferase activity
- sterol O-acyltransferase activity