Slc30a2 Gene Summary [Rat]
The protein encoded by this gene is a zinc transporter. It is localized in the vesicles and suggested to protect the cells from zinc toxicity by facilitating vesicular sequestration. Alternatively spliced transcript variants have been found for this gene, one of which initiates translation from a non-AUG (CUG) start codon. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | Slc30a2 |
| Official Name | solute carrier family 30 member 2 [Source:RGD Symbol;Acc:3707] |
| Ensembl ID | ENSRNOG00000054142 |
| Bio databases IDs | |
| Aliases | solute carrier family 30 member 2 |
| Synonyms | LOC100505248, LOC100911760, PP12488, solute carrier family 30 member 2, solute carrier family 30 (zinc transporter), member 2, TNZD, ZNT2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc30a2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hydrogen ion transporter
- cation diffusion facilitator family transporter
- antiporter
- protein binding
- zinc ion transporter
- Cation efflux family
- metal ion transporter
- identical protein binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- transient neonatal zinc deficiency
- renal clear cell adenocarcinoma
- renal clear cell cancer
regulated by
- cisplatin
- Immunoglobulin
- dexamethasone
- heavy metal
- decitabine
- PF-3893787
- zinc pyrithione
- histamine
- zinc chloride
role in cell
- apoptosis
- function
- formation
- biogenesis
- development in
- biogenesis in
- formation in
- degradation in
- acidification in
- acidification
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- endosomal membrane fractions
- intracellular membrane-bounded organelle
- Cytoplasm
- cellular membrane
- mitochondrial inner membrane
- lysosome membrane
- endosomal membrane
- zymogen granules
- late endosomes
- secretory vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc30a2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to zinc ion
- cellular zinc ion homeostasis
- zinc ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- transport vesicle membrane
- cytoplasm
- intracellular membrane-bounded organelle
- late endosome
- endosome membrane
- plasma membrane
- mitochondrial inner membrane
- lysosomal membrane
- zymogen granule membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- metal ion binding
- zinc ion transmembrane transporter activity