Cd52 Gene Summary [Rat]
Predicted to be involved in positive regulation of cytosolic calcium ion concentration. Predicted to act upstream of or within response to bacterium. Predicted to be located in plasma membrane and side of membrane. Predicted to be active in sperm midpiece. Orthologous to human CD52 (CD52 molecule). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cd52 |
| Official Name | CD52 molecule [Source:RGD Symbol;Acc:620627] |
| Ensembl ID | ENSRNOG00000015403 |
| Bio databases IDs | |
| Aliases | CD52 molecule |
| Synonyms | B7, B7-Ag, CAMPATH-1, CD52 antigen, CD52 molecule, CDW52, CLS1, EDDM5, HE5, MB7 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cd52 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CAMPATH-1 antigen
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- T acute lymphoblastic leukemia
- acute myeloid leukemia
- Sézary syndrome
- atherosclerosis
- vasculitis
- microscopic polyangiitis
- prostate cancer
- refractory chronic lymphocytic leukemia
- leukemia
- non-small cell lung cancer
role in cell
- induction
- elevation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
- cellular membrane
- sperm midpiece
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cd52 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- respiratory burst
- elevation of cytosolic calcium ion concentration
Cellular Component
Where in the cell the gene product is active
- sperm midpiece
- membrane
- extracellular region
- plasma membrane