Dnajb4 Gene Summary [Rat]
Predicted to enable ATPase activator activity; protein-folding chaperone binding activity; and unfolded protein binding activity. Predicted to be involved in chaperone cofactor-dependent protein refolding and negative regulation of transcription by RNA polymerase II. Predicted to be located in Z disc; nucleoplasm; and plasma membrane. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in congenital myopathy 21. Orthologous to human DNAJB4 (DnaJ heat shock protein family (Hsp40) member B4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dnajb4 |
| Official Name | DnaJ heat shock protein family (Hsp40) member B4 [Source:RGD Symbol;Acc:1305826] |
| Ensembl ID | ENSRNOG00000013011 |
| Bio databases IDs | |
| Aliases | DnaJ heat shock protein family (Hsp40) member B4 |
| Synonyms | 1700029A20Rik, 2010306G19RIK, 5730460G06RIK, CMYO21, CMYP21, DjB4, DnaJ heat shock protein family (Hsp40) member B4, DNAJW, HLJ1, LOC100359900 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dnajb4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DnaJ domain
- ATPase stimulator
- chaperone protein DnaJ
- DnaJ
- DnaJ molecular chaperone homology domain
- DnaJ C terminal domain
- protein binding
- chaperone binding
Pathways
Biological processes and signaling networks where the Dnajb4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- congestive heart failure
- obesity
- weight gain
- non-small cell lung cancer
- organismal death
- lung adenocarcinoma
- lung adenocarcinoma formation
- cutaneous melanoma
- cutaneous melanoma cancer
- peripheral arterial disease
role in cell
- proliferation
- growth
- phosphorylation in
- invasion by
- binding in
- cell cycle progression
- motility
- tumorigenicity
- invasiveness
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Plasma Membrane
- cytosol
- nucleoplasm
- nucleoli
- Z line
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dnajb4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- response to heat
- chaperone mediated protein folding requiring cofactor
- response to unfolded protein
Cellular Component
Where in the cell the gene product is active
- Z disc
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- chaperone binding
- unfolded protein binding
- ATPase activator activity