Dsc1 Gene Summary [Rat]
Predicted to enable calcium ion binding activity. Predicted to be involved in several processes, including desmosome maintenance; negative regulation of epithelial cell proliferation; and skin epidermis development. Predicted to be located in plasma membrane. Predicted to be active in desmosome. Orthologous to human DSC1 (desmocollin 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dsc1 |
| Official Name | desmocollin 1 [Source:RGD Symbol;Acc:1310768] |
| Ensembl ID | ENSRNOG00000056258 |
| Bio databases IDs | |
| Aliases | desmocollin 1 |
| Synonyms | 1110020A10Rik, CDHF1, desmocollin 1, DG2/DG3, DGIV/V, LOC102555477 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dsc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Cadherin, Y-type LIR-motif
- Cadherin prodomain like
- cytoplasmic domain
- intracellular domain
- Cadherin repeat-like domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Netherton syndrome
- peeling of skin
- psoriasis
- acantholysis
- comedones
- hyperplasia
- alopecia
- microphthalmia
- eyelids open at birth
- dermatitis
regulates
- ERK
- keratin II, 6
- keratin 16
role in cell
- proliferation
- differentiation
- accumulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cornified envelope
- cell surface
- cell borders
- cellular membrane
- desmosomes
- secretory granule membrane
- gap junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dsc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- homophilic cell adhesion
Cellular Component
Where in the cell the gene product is active
- gap junction
- cornified envelope
- extracellular vesicular exosome
- membrane
- desmosome
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding