Crk Gene Summary [Rat]
Enables several functions, including insulin-like growth factor receptor binding activity; protein tyrosine kinase binding activity; and scaffold protein binding activity. Involved in several processes, including cellular response to nitric oxide; cellular response to peptide hormone stimulus; and regulation of intracellular signal transduction. Predicted to be located in actin cytoskeleton and membrane. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and neuromuscular junction. Biomarker of degenerative disc disease. Orthologous to human CRK (CRK proto-oncogene, adaptor protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Crk |
| Official Name | CRK proto-oncogene, adaptor protein [Source:RGD Symbol;Acc:2405] |
| Ensembl ID | ENSRNOG00000025792 |
| Bio databases IDs | |
| Aliases | CRK proto-oncogene, adaptor protein |
| Synonyms | c-Crk, c-Crk2, CRK2, Crko, CRK proto-oncogene, adaptor protein, FLJ11558, p38, v-crk avian sarcoma virus CT10 oncogene homolog |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Crk often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- protein kinase binding
- nuclear export signal
- SH2-domain binding
- protein binding activity, bridging
- enzyme binding
- ephrin receptor binding
- protein domain specific binding
- phosphotyrosine binding
- protein binding
- insulin-like growth factor receptor binding
- SH3-domain binding
- phosphoprotein amino acid binding
- Src Homology 3 domain superfamily
- kinase binding
- cytoskeletal protein binding
- receptor signaling complex scaffold protein
- Bcl-2 homology 3 domain
- Src homology 2 (SH2) domain
Pathways
Biological processes and signaling networks where the Crk gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Angiopoietin Signaling
- Chronic Myeloid Leukemia Signaling
- CXCR4 Signaling
- Ephrin Receptor Signaling
- Epithelial Adherens Junction Signaling
- ERK/MAPK Signaling
- FGF Signaling
- G-Protein Coupled Receptor Signaling
- Insulin Receptor Signaling
- Integrin Signaling
- Leukocyte Extravasation Signaling
- Melanocyte Development and Pigmentation Signaling
- Molecular Mechanisms of Cancer
- Neuregulin Signaling
- NGF Signaling
- Paxillin Signaling
- PDGF Signaling
- Reelin Signaling in Neurons
- Renal Cell Carcinoma Signaling
- SAPK/JNK Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- major depression
- inflammatory bowel disease
- non-insulin-dependent diabetes mellitus
- lung cancer
- hydrops fetalis
- ovarian cancer
- hypertension
- bleeding
- palatal shelves fail to meet at midline
role in cell
- differentiation
- phosphorylation in
- formation
- growth
- cell viability
- apoptosis
- binding in
- activation in
- signaling in
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell periphery
- cellular membrane
- focal adhesions
- actin cytoskeleton
- Nucleus
- Plasma Membrane
- cytosol
- membrane ruffles
- neuromuscular junctions
- growth cone
- neurites
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Crk gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of Rac protein signal transduction
- regulation of cell shape
- cell proliferation
- helper T cell diapedesis
- cell chemotaxis
- regulation of dendrite development
- neuron migration
- cellular response to nitric oxide
- positive regulation of smooth muscle cell migration
- cell migration
- dendrite development
- reelin-mediated signaling pathway
- negative regulation of wound healing
- hippocampus development
- response to hydrogen peroxide
- enzyme linked receptor protein signaling pathway
- positive regulation of substrate adhesion-dependent cell spreading
- cerebral cortex development
- regulation of signal transduction
- negative regulation of natural killer cell mediated cytotoxicity
- regulation of transcription from RNA polymerase II promoter
- cellular response to transforming growth factor beta stimulus
- regulation of cell adhesion mediated by integrin
- regulation of actin cytoskeleton organization
- regulation of T cell migration
- response to hepatocyte growth factor stimulus
- positive regulation of JNK cascade
- response to yeast
- regulation of GTPase activity
- lipid metabolic process
- ephrin receptor signaling pathway
- negative regulation of cell motility
- protein localization in membrane
- establishment of cell polarity
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoplasm
- membrane
- actin cytoskeleton
- cytosol
- neuromuscular junction
- macromolecular complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein phosphorylated amino acid binding
- signaling adaptor activity
- ephrin receptor binding
- SH2 domain binding
- insulin-like growth factor receptor binding
- phosphotyrosine binding
- scaffold protein binding
- ubiquitin protein ligase binding
- protein binding
- SH3 domain binding
- cytoskeletal protein binding
- receptor tyrosine kinase binding
- kinase binding
- receptor signaling complex scaffold activity