Dsg1 Gene Summary [Rat]
Predicted to enable calcium ion binding activity and gamma-catenin binding activity. Involved in maternal process involved in female pregnancy and response to progesterone. Located in apical plasma membrane and lateral plasma membrane. Human ortholog(s) of this gene implicated in keratosis palmoplantaris striata 1. Orthologous to human DSG1 (desmoglein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dsg1 |
| Official Name | desmoglein 1 [Source:RGD Symbol;Acc:1309925] |
| Ensembl ID | ENSRNOG00000016853 |
| Bio databases IDs | |
| Aliases | desmoglein 1 |
| Synonyms | CDHF4, desmoglein 1, DG1, DSG, Dsg1b, Dsg1c, EPKHE, EPKHIA, LOC679010, PPKS1, SPPK1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dsg1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Cadherin, Y-type LIR-motif
- cytoplasmic domain
- gamma-catenin binding
- ectodomain
- intracellular domain
- Cadherin repeat-like domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- eosinophilic esophagitis
- Palmoplantar keratoderma striata form I
- Netherton syndrome
- psoriasis
- congenital erythroderma with palmoplantar keratoderma, hypotrichosis, and hyper-IgE
- focal palmoplantar keratoderma striata I
- acantholysis
role in cell
- expression in
- apoptosis
- proliferation
- adhesion
- assembly
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cornified envelope
- Cytoplasm
- cell borders
- cell periphery
- membrane surface
- cellular membrane
- Nucleus
- intercellular junctions
- desmosomes
- cell-cell contacts
- secretory granule membrane
- cytosol
- cytoplasmic face of plasma membrane
- apical membrane
- lateral plasma membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dsg1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- calcium-dependent cell-cell adhesion
- maternal process involved in female pregnancy
- cell-cell junction assembly
- response to progesterone stimulus
- homophilic cell adhesion
- protein stabilization
Cellular Component
Where in the cell the gene product is active
- nucleus
- cornified envelope
- lateral plasma membrane
- cell-cell junction
- cytoplasm
- cytosol
- desmosome
- apical plasma membrane
- plasma membrane
- internal side of plasma membrane
Molecular Function
What the gene product does at the molecular level
- toxin binding
- gamma-catenin binding
- protein binding
- calcium ion binding