Kcnh8 Gene Summary [Rat]
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and delayed rectifier potassium channel activity. Involved in negative regulation of apoptotic process; potassium ion transport; and response to aldosterone. Predicted to be part of monoatomic ion channel complex. Predicted to be active in plasma membrane. Biomarker of retinal degeneration. Orthologous to human KCNH8 (potassium voltage-gated channel subfamily H member 8). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kcnh8 |
| Official Name | potassium voltage-gated channel subfamily H member 8 [Source:RGD Symbol;Acc:2549] |
| Ensembl ID | ENSRNOG00000058626 |
| Bio databases IDs | |
| Aliases | potassium voltage-gated channel subfamily H member 8 |
| Synonyms | C130090D05RIK, ELK, ELK1, ELK3, Ets-1, hElk-1, Kv12.1, LOC100504205, potassium voltage-gated channel, subfamily H (eag-related), member 8, potassium voltage-gated channel subfamily H member 8, RELK3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Kcnh8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- delayed rectifier potassium channel
- Ion transport protein
- nucleic acid binding
- PAS domain S-box
- PAS
- sequence-specific DNA binding
- ion channel
- PAS fold
- Cyclic nucleotide-monophosphate binding domain
- Cyclic nucleotide-binding domain
- voltage-gated potassium channel
- PAS domain
- double-stranded DNA binding
- Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)
- CAP_ED
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- chronic venous insufficiency
- major depression
- progressive myoclonic epilepsy type 4 with renal failure
- angina pectoris
regulates
- K+
role in cell
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- nuclear fraction
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Kcnh8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of membrane potential
- potassium ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- ion channel complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- voltage-gated potassium channel activity