Ptger3 Gene Summary [Rat]
Enables prostaglandin E receptor activity. Involved in several processes, including regulation of circadian sleep/wake cycle; regulation of gastro-intestinal system smooth muscle contraction; and regulation of secretion. Located in several cellular components, including brush border membrane; nuclear membrane; and proximal neuron projection. Used to study asthma and withdrawal disorder. Biomarker of colon cancer; membranous glomerulonephritis; and renovascular hypertension. Orthologous to human PTGER3 (prostaglandin E receptor 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ptger3 |
| Official Name | prostaglandin E receptor 3 [Source:RGD Symbol;Acc:3435] |
| Ensembl ID | ENSRNOG00000010325 |
| Bio databases IDs | |
| Aliases | prostaglandin E receptor 3 |
| Synonyms | EP3, Ep3b, Ep3 gamma, EP3R, Ep3 γ, lnc003875, PGE2-R, Pgerep3, prostaglandin E receptor 3, prostaglandin E receptor 3 (subtype EP3), Ptgerep3, Rep3, rEP3a, rEP3b |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ptger3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- intracellular loop
- prostaglandin E receptor
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Ptger3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hyperglycemia
- obesity
- pain
- weight gain
- diabetes mellitus
- primary open-angle glaucoma
- prostate cancer
- endometriosis
- chronic kidney disease
- open-angle glaucoma
role in cell
- expression in
- cell death
- apoptosis
- activation in
- synthesis in
- response
- size
- binding in
- activation
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cell surface
- perinuclear region
- cellular membrane
- nuclear envelope
- neurites
- brush border
- perikaryon
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ptger3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- cell death
- G-protein coupled receptor signaling pathway
- intestine smooth muscle contraction
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- phospholipase C-activating G-protein coupled receptor signaling pathway
- positive regulation of fever generation
- negative regulation of gastric acid secretion
- elevation of cytosolic calcium ion concentration
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- prostaglandin E receptor activity