Popdc2 Gene Summary [Rat]
Predicted to enable cAMP binding activity. Predicted to be involved in several processes, including heart development; skeletal muscle tissue development; and striated muscle cell differentiation. Predicted to act upstream of or within regulation of heart rate and sinoatrial node cell development. Predicted to be located in membrane. Predicted to be active in sarcolemma. Orthologous to human POPDC2 (popeye domain cAMP effector 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Popdc2 |
| Official Name | popeye domain containing 2 [Source:RGD Symbol;Acc:735226] |
| Ensembl ID | ENSRNOG00000058752 |
| Bio databases IDs | |
| Aliases | popeye domain containing 2 |
| Synonyms | AV006127, LOC100910206, POP2, popeye domain cAMP effector 2, popeye domain containing 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Popdc2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 3',5'-cAMP binding
- Popeye protein conserved region
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- uterine leiomyoma
- leiomyomatosis
- soft tissue sarcoma cancer
- leiomyosarcoma
- preeclampsia
regulated by
- L-triiodothyronine
- D-glucose
- ASPSCR1-TFE3
- THRA
role in cell
- expression in
- production in
- transmembrane potential
- inhibition in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- sarcolemma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Popdc2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heart development
- regulation of heart rate
- striated muscle cell differentiation
- regulation of membrane potential
- skeletal muscle tissue development
Cellular Component
Where in the cell the gene product is active
- sarcolemma
- membrane
Molecular Function
What the gene product does at the molecular level
- cAMP binding