Slc8a1 Gene Summary [Rat]
Enables calcium:sodium antiporter activity. Involved in several processes, including cellular response to cAMP; metal ion transport; and regulation of heart contraction. Located in several cellular components, including T-tubule; Z disc; and dendrite. Is active in postsynaptic membrane. Used to study brain ischemia. Biomarker of brain ischemia; congestive heart failure; hypertension; and status epilepticus. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human SLC8A1 (solute carrier family 8 member A1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc8a1 |
| Official Name | solute carrier family 8 member A1 [Source:RGD Symbol;Acc:3717] |
| Ensembl ID | ENSRNOG00000008479 |
| Bio databases IDs | |
| Aliases | solute carrier family 8 member A1 |
| Synonyms | AI852629, AV344025, CARDIAC NA+/CA2+ EXCHANGER, D930008O12RIK, LOC108351162, Ncx, NCX1, solute carrier family 8 member A1, solute carrier family 8 (sodium/calcium exchanger), member 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc8a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium:sodium antiporter
- calmodulin binding
- calcium ion binding
- sodium/calcium exchanger 1
- C-terminal extension of sodium/calcium exchanger domain
- calcium binding loop
- protein binding
- Domains in Na-Ca exchangers and integrin-beta4
- cytoskeletal protein binding
- ankyrin binding
- calcium:cation antiporter
- antiporter
- ion channel binding
- Sodium/calcium exchanger protein
- Calx-beta domain
- transporter
Pathways
Biological processes and signaling networks where the Slc8a1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- heart failure
- obesity
- diabetic nephropathy
- renal cell carcinoma
- renal cell cancer
- fracture of bone
- coronary artery disease
- hypertriglyceridemia
- chromophobe renal cell carcinoma
role in cell
- proliferation
- expression in
- production in
- phosphorylation in
- migration
- differentiation
- formation
- formation in
- apoptosis
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent-soluble membrane fractions
- membrane fraction
- cell surface
- cell periphery
- cellular membrane
- microtubules
- intercellular junctions
- postsynaptic membrane
- basolateral membrane
- lateral plasma membrane
- nucleoplasm
- dendritic spines
- synapse
- intercalated disks
- sarcolemma
- Z line
- transverse tubules
- cellular protrusions
- perikaryon
- axons
- dendrites
- postsynaptic density
- axon terminals
- dendritic shafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc8a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- calcium ion import
- calcium ion homeostasis
- membrane depolarization involved in regulation of cardiac muscle cell action potential
- cellular sodium ion homeostasis
- relaxation of smooth muscle
- cardiac muscle contraction
- calcium ion transport into cytosol
- ion transport
- muscle contraction
- calcium ion transmembrane transport
- cellular response to caffeine
- cell communication by electrical coupling involved in cardiac conduction
- response to muscle stretch
- positive regulation of bone mineralization
- reduction of cytosolic calcium ion concentration
- cellular calcium ion homeostasis
- regulation of the force of heart contraction
- regulation of heart rate
- vascular smooth muscle contraction
- regulation of cell communication by electrical coupling
- regulation of gene expression
- cardiac muscle cell development
- sodium ion transmembrane transport
- negative regulation of protein serine/threonine kinase activity
- regulation of cardiac muscle contraction by calcium ion signaling
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
- relaxation of cardiac muscle
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- neuronal cell body
- synapse
- plasma membrane
- axon terminus
- nucleoplasm
- Z disc
- T-tubule
- dendrite
- sarcolemma
- intercalated disc
- axon
- cell periphery
Molecular Function
What the gene product does at the molecular level
- calmodulin binding
- protein binding
- ankyrin binding
- calcium ion binding
- cytoskeletal protein binding
- calcium:sodium antiporter activity
- ion channel binding