Dsg4 Gene Summary [Rat]
Enables calcium ion binding activity. Predicted to be involved in cell-cell adhesion. Predicted to act upstream of or within BMP signaling pathway; hair follicle development; and keratinocyte differentiation. Predicted to be located in plasma membrane. Predicted to be active in desmosome. Used to study alopecia and hypotrichosis. Human ortholog(s) of this gene implicated in hypotrichosis and hypotrichosis 6. Orthologous to human DSG4 (desmoglein 4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dsg4 |
| Official Name | desmoglein 4 [Source:RGD Symbol;Acc:735015] |
| Ensembl ID | ENSRNOG00000022364 |
| Bio databases IDs | |
| Aliases | desmoglein 4 |
| Synonyms | CDGF13, CDHF13, desmoglein 4, HYPT6, LAH |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dsg4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cadherin, Y-type LIR-motif
- calcium ion binding
- Cadherin repeat-like domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypotrichosis type 6
- androgenic alopecia
regulates
- Krtap5-2
- Krt31 (includes others)
- Krtap19-3
- Krtap19-1
- Krtap9-1/Krtap9-21
- Krtap6-5
- Krtap19-4
- Krtap4-16
- Krtap21-1
- Krt86
role in cell
- proliferation
- differentiation
- attachment
- adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cornified envelope
- cell borders
- cellular membrane
- Mitochondria
- desmosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dsg4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- keratinocyte differentiation
- hair follicle development
- BMP signaling pathway
- homophilic cell adhesion
Cellular Component
Where in the cell the gene product is active
- cornified envelope
- desmosome
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- calcium ion binding