Ldb3 Gene Summary [Rat]
Enables enzyme binding activity. Predicted to be involved in actin cytoskeleton organization; heart development; and muscle structure development. Predicted to act upstream of or within sarcomere organization. Located in Z disc. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; dilated cardiomyopathy 1C; distal myopathy; and myofibrillar myopathy 4. Orthologous to human LDB3 (LIM domain binding 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ldb3 |
| Official Name | LIM domain binding 3 [Source:RGD Symbol;Acc:1564875] |
| Ensembl ID | ENSRNOG00000059166 |
| Bio databases IDs | |
| Aliases | LIM domain binding 3 |
| Synonyms | CMD1C, CMH24, CMPD3, CYPHER, LDB3Z1, LDB3Z4, LIM Domain Binding 3, LVNC3, MFM4, ORACLE, PDLIM6, RGD1564875, ZASP |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ldb3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain of unknown function (DUF4749)
- Domain present in PSD-95, Dlg, and ZO-1/2
- LIM is a small protein-protein interaction domain, containing two zinc fingers
- actinin binding
- protein kinase C binding
- canonical PDZ domain
- enzyme binding
- protein binding
- PDZ domain
- Domain of unknown function (DUF3432)
- YS/TPS/TP repeat
- cytoskeletal protein binding
- ZASP-like motif
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cardiomyopathy
- myocardial infarction
- squamous cell cancer of the oral cavity
- breast cancer
- myofibrilliar myopathy ZASP-related
- glioblastoma
- glioblastoma cancer
- dilated cardiomyopathy 1C
- dilated cardiomyopathy with left ventricular noncompaction type 1c
- oral squamous cell carcinoma
regulates
- F Actin
role in cell
- accumulation in
- assembly
- maintenance
- structural integrity
- disruption in
- sarcomerogenesis in
- disruption
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoskeleton
- perinuclear region
- myofibrils
- intercalated disks
- Z line
- zonula adherens
- pseudopodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ldb3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heart development
- sarcomere organization
- muscle structure development
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- Z disc
- adherens junction
- perinuclear region of cytoplasm
- cytoskeleton
- stress fiber
- pseudopodium
- filamentous actin
Molecular Function
What the gene product does at the molecular level
- protein kinase C binding
- protein binding
- actin binding
- metal ion binding
- muscle alpha-actinin binding
- cytoskeletal protein binding