Actg1 Gene Summary [Rat]
A structural constituent of postsynaptic actin cytoskeleton. Involved in response to calcium ion and response to mechanical stimulus. Is active in postsynaptic actin cytoskeleton and presynaptic actin cytoskeleton. Human ortholog(s) of this gene implicated in Baraitser-Winter syndrome 2 and autosomal dominant nonsyndromic deafness 20. Orthologous to human ACTG1 (actin gamma 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Actg1 |
| Official Name | actin, gamma 1 [Source:RGD Symbol;Acc:1304556] |
| Ensembl ID | ENSRNOG00000036701 |
| Bio databases IDs | |
| Aliases | actin, gamma 1 |
| Synonyms | ACT, ACTG, actin gamma 1, actin, gamma 1, actin, gamma, cytoplasmic 1, Actin γ, actin γ 1, actin, γ 1, actin, γ, cytoplasmic 1, ACTL, beta-actin, Chi-actin, DFNA20, DFNA26, E51, G-actin, gamma ACTIN, HEL-176, LOC295810, β-actin, γ ACTIN |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Actg1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- structural constituent of cytoskeleton
- Actin
- protein binding
- structural molecule
- identical protein binding
- ASKHA_ATPase-like
- profilin binding
Pathways
Biological processes and signaling networks where the Actg1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Agranulocyte Adhesion and Diapedesis
- Agrin Interactions at Neuromuscular Junction
- Caveolar-mediated Endocytosis Signaling
- Cellular Effects of Sildenafil (Viagra)
- Clathrin-mediated Endocytosis Signaling
- Death Receptor Signaling
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- Gap Junction Signaling
- Germ Cell-Sertoli Cell Junction Signaling
- ILK Signaling
- Leukocyte Extravasation Signaling
- Mechanisms of Viral Exit from Host Cells
- MSP-RON Signaling Pathway
- NRF2-mediated Oxidative Stress Response
- Paxillin Signaling
- Remodeling of Epithelial Adherens Junctions
- RhoA Signaling
- RhoGDI Signaling
- Sertoli Cell-Sertoli Cell Junction Signaling
- TEC Kinase Signaling
- Tight Junction Signaling
- Virus Entry via Endocytic Pathways
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- autosomal dominant deafness type 20
- Baraitser-Winter syndrome type 2
- hereditary disorder
- recurrent childhood acute lymphoblastic leukemia
- lissencephaly
- hepatocellular carcinoma
- liver cancer
- congenital anomalies of kidney and urinary tract
- Baraitser-Winter syndrome
role in cell
- activation in
- expression in
- growth
- number
- migration
- fragmentation
- fragmentation in
- polymerization in
- development
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- extracellular vesicles
- cytoskeleton
- cell periphery
- apical compartment
- punctate structures
- focal adhesions
- actin cytoskeleton
- Nucleus
- Plasma Membrane
- costameres
- actin filaments
- intercellular junctions
- lipid droplets
- cytosol
- subcortical actin network
- microsome
- plasma membrane projections
- Golgi membrane
- nucleoli
- growth cone
- neurites
- synapse
- myofibrils
- I band
- m-bands
- sarcolemma
- Z line
- actin stress fibers
- filopodia
- perikaryon
- axons
- axon terminals
- exosomes
- phagosomes
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Actg1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of wound healing
- regulation of synaptic vesicle endocytosis
- sarcomere organization
- regulation of stress fiber assembly
- cell motility
- regulation of focal adhesion assembly
- angiogenesis
- axonogenesis
- positive regulation of gene expression
- morphogenesis of a polarized epithelium
- cellular response to interferon-gamma
- platelet aggregation
- maintenance of blood-brain barrier
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- NuA4 histone acetyltransferase complex
- phagocytic vesicle
- synapse
- actin filament
- plasma membrane
- calyx of Held
- nucleus
- extracellular space
- cell-cell junction
- extracellular vesicular exosome
- cytoskeleton
- focal adhesion
- cytoplasm
- apical junction complex
- membrane
- blood microparticle
- actin cytoskeleton
- cytosol
- filamentous actin
- axon
- myofibril
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- ATP binding
- identical protein binding
- protein binding
- ubiquitin protein ligase binding
- structural constituent of cytoskeleton
- hydrolase activity
- profilin binding