Prps1 Gene Summary [Rat]
Enables several functions, including magnesium ion binding activity; purine ribonucleotide binding activity; and ribose phosphate diphosphokinase activity. Involved in 5-phosphoribose 1-diphosphate biosynthetic process; AMP biosynthetic process; and animal organ regeneration. Part of ribose phosphate diphosphokinase complex. Human ortholog(s) of this gene implicated in Arts syndrome; X-linked deafness 1; X-linked recessive disease (multiple); gout; and retinitis pigmentosa. Orthologous to human PRPS1 (phosphoribosyl pyrophosphate synthetase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prps1 |
| Official Name | phosphoribosyl pyrophosphate synthetase 1 [Source:RGD Symbol;Acc:61955] |
| Ensembl ID | ENSRNOG00000060262 |
| Bio databases IDs | |
| Aliases | phosphoribosyl pyrophosphate synthetase 1 |
| Synonyms | 2310010D17Rik, ARTS, C76571, CMTX5, DFN2, DFNX1, phosphoribosyl pyrophosphate synthetase 1, PPRibP, PRS-I |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Prps1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ADP binding
- ribose-phosphate diphosphokinase
- ATP binding
- ATP phosphoribosyltransferase
- Phosphoribosyl transferase (PRT)-type I domain
- Phosphoribosyl synthetase-associated domain
- protein binding
- magnesium ion binding
- N-terminal domain of ribose phosphate pyrophosphokinase
- identical protein binding
- PRK00934
- kinase
- AMP binding
- GDP binding
- protein homodimerization
- ribose-phosphate pyrophosphokinase
- carbohydrate binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- X-linked deafness type 1
- phosphoribosylpyrophosphate synthetase superactivity
- Arts syndrome and phosphoribosylpyrophosphate synthetase superactivity
- Charcot-Marie-Tooth disease, X-linked recessive, type 5
- Charcot-Marie-Tooth disease
- hereditary disorder
- ulcerative colitis
- colorectal cancer
- neoplasia
- retinal dystrophy
role in cell
- migration
- proliferation
- degradation in
- apoptosis
- etoposide sensitivity
- invasion by
- synthesis in
- molecular cleavage in
- replication in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- cytoplasmic droplets
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Prps1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- urate biosynthetic process
- hypoxanthine biosynthetic process
- ribonucleoside monophosphate biosynthetic process
- purine nucleotide biosynthetic process
- nervous system development
- purine base metabolic process
- pyrimidine nucleotide biosynthetic process
- 5-phosphoribose 1-diphosphate biosynthetic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- ribose phosphate diphosphokinase complex
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ATP binding
- identical protein binding
- protein binding
- protein homodimerization activity
- ribose phosphate diphosphokinase activity
- kinase activity