Xiap Gene Summary [Rat]
Enables protease binding activity and scaffold protein binding activity. Involved in cellular response to hydrogen peroxide and negative regulation of neuron apoptotic process. Located in perinuclear region of cytoplasm. Part of protein-containing complex. Human ortholog(s) of this gene implicated in X-linked lymphoproliferative syndrome 2 and prostate cancer. Orthologous to several human genes including XIAP (X-linked inhibitor of apoptosis). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Xiap |
| Official Name | X-linked inhibitor of apoptosis [Source:RGD Symbol;Acc:620692] |
| Ensembl ID | ENSRNOG00000006967 |
| Bio databases IDs | |
| Aliases | X-linked inhibitor of apoptosis |
| Synonyms | 1110015C02RIK, Aipa, API3, APOPTOSIS INHIBITOR3, BIRC4, hIAP-3, IAP-3, ILP-1, LOC103694512, MIHA, riap3, Xiap-4, X-linked inhibitor of apoptosis, XLP2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Xiap often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBA domain-like superfamily
- protein kinase binding
- Bir domain
- protease binding
- ubiquitin protein ligase activity
- caspase inhibitor activity
- linker domain
- enzyme
- enzyme regulator activity
- protein binding
- identical protein binding
- phosphorylation site
- BIR3 domain
- cysteine protease inhibitor activity
- BIR1 domain
- BIR
- spacer domain
- ubiquitination site
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- ubiquitin-protein transferase activity
- BIR2 domain
- Zinc finger, C3HC4 type (RING finger)
Pathways
Biological processes and signaling networks where the Xiap gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Amyotrophic Lateral Sclerosis Signaling
- Apoptosis Signaling
- BMP signaling pathway
- Chronic Myeloid Leukemia Signaling
- Death Receptor Signaling
- EIF2 Signaling
- Erythropoietin Signaling
- HER-2 Signaling in Breast Cancer
- Induction of Apoptosis by HIV1
- Molecular Mechanisms of Cancer
- Mouse Embryonic Stem Cell Pluripotency
- Neuroinflammation Signaling Pathway
- Protein Ubiquitination Pathway
- RANK Signaling in Osteoclasts
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- TNFR1 Signaling
- TNFR2 Signaling
- TWEAK Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- neoplasia
- amyotrophic lateral sclerosis
- bleeding
- lymphoma
- childhood acute lymphoblastic leukemia
- acute myeloid leukemia
- experimental autoimmune encephalomyelitis
- hepatitis
- congestive heart failure
role in cell
- proliferation
- phosphorylation in
- binding in
- formation
- formation in
- apoptosis
- expression in
- activation in
- growth
- accumulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Nucleus
- Plasma Membrane
- cytoplasmic aggregates
- cytosol
- nucleoplasm
- membrane rafts
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Xiap gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- regulation of apoptosis involved in tissue homeostasis
- copper ion homeostasis
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
- positive regulation of protein ubiquitination
- regulation of nucleotide-binding oligomerization domain containing signaling pathway
- Wnt receptor signaling pathway
- regulation of cell cycle
- nucleotide-binding oligomerization domain containing 1 signaling pathway
- neuron apoptotic process
- positive regulation of type I interferon production
- positive regulation of canonical Wnt receptor signaling pathway
- regulation of apoptotic process
- response to DNA damage stimulus
- defense response to bacterium
- regulation of cell proliferation
- nucleotide-binding oligomerization domain containing 2 signaling pathway
- negative regulation of tumor necrosis factor-mediated signaling pathway
- positive regulation of JNK cascade
- negative regulation of apoptotic process
- regulation of innate immune response
- regulation of inflammatory response
- protein K63-linked ubiquitination
- regulation of BMP signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- identical protein binding
- endopeptidase regulator activity
- protein binding
- cysteine-type endopeptidase inhibitor activity
- metal ion binding
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process