Lmo7 Gene Summary [Rat]
Enables actinin binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in adherens junction and apical plasma membrane. Orthologous to human LMO7 (LIM domain 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lmo7 |
| Official Name | LIM domain 7 [Source:RGD Symbol;Acc:1302984] |
| Ensembl ID | ENSRNOG00000060775 |
| Bio databases IDs | |
| Aliases | LIM domain 7 |
| Synonyms | C130003G01, E030010D13, FBX20, FBXO20, Gm914, KIAA0858, LIM domain 7, LIM domain only 7, LMO7b, LOMP, mKIAA0858, ZFDCP |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Lmo7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain present in PSD-95, Dlg, and ZO-1/2
- Domain of unknown function (DUF4757)
- Calponin homology domain
- LIM is a small protein-protein interaction domain, containing two zinc fingers
- actinin binding
- calponin homology (CH) domain superfamily
- canonical PDZ domain
- enzyme
- protein binding
- PDZ domain
- cpPDZ_Deg_HtrA-like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- epithelial neoplasia
- cancer
- prostate cancer
- prostatic carcinoma
- COVID-19
- breast carcinoma
- Huntington disease
- glaucoma
- cutaneous melanoma cancer
role in cell
- migration
- activation in
- inhibition in
- docetaxel resistance
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- cell surface
- Nucleus
- Plasma Membrane
- Mitochondria
- cell-cell contacts
- cytosol
- apical membrane
- basolateral membrane
- nuclear envelope
- cell-cell adherens junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Lmo7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of signaling
- regulation of cell adhesion
- positive regulation of transcription from RNA polymerase II promoter
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- nucleus
- ubiquitin ligase complex
- focal adhesion
- cytoplasm
- cytosol
- apical plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- metal ion binding