Mrtfa Gene Summary [Rat]
Predicted to enable several functions, including actin monomer binding activity; leucine zipper domain binding activity; and transcription coactivator activity. Involved in several processes, including negative regulation of apoptotic process; positive regulation of cell differentiation; and positive regulation of collagen biosynthetic process. Located in cytosol and nucleus. Is active in glutamatergic synapse; postsynapse; and presynapse. Biomarker of Alzheimer's disease and transient cerebral ischemia. Human ortholog(s) of this gene implicated in acute megakaryocytic leukemia and immunodeficiency 66. Orthologous to human MRTFA (myocardin related transcription factor A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mrtfa |
| Official Name | myocardin related transcription factor A [Source:RGD Symbol;Acc:1304873] |
| Ensembl ID | ENSRNOG00000018803 |
| Bio databases IDs | |
| Aliases | myocardin related transcription factor A |
| Synonyms | AMKL, BSAC, FLMKL1, MAL, MELODY, MKL, MKL1, MKL1met, myocardin related transcription factor A |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mrtfa often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-activator
- SAP motif
- RPEL repeat
- nucleic acid binding
- SAP domain
- LRR-domain binding
- transcription activation domain
- coiled-coil domain
- protein binding
- glutamine-rich domain
- sequence-specific DNA binding
- actin monomer binding
- double-stranded DNA binding
- actin binding
- basic domain
- transcription factor activity
Pathways
Biological processes and signaling networks where the Mrtfa gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- coronary artery disease
- neoplasia
- thrombocytopenia
- obesity
- myocardial infarction
- edema
- pulmonary hypertension
- cancer
- cardiac hypertrophy
- breast cancer
role in cell
- proliferation
- expression in
- cell death
- apoptosis
- activation in
- formation
- adhesion
- cell spreading
- quantity
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- glutaminergic synapse
- Cytoplasm
- presynaptic regions
- postsynaptic region
- cytosol
- nucleoplasm
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mrtfa gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- wound healing, spreading of cells
- smooth muscle cell differentiation
- positive regulation of transcription from RNA polymerase II promoter
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- actin binding
- transcription coactivator activity
- leucine zipper domain binding
- actin monomer binding