Qars1 Gene Summary [Rat]
Predicted to enable glutamine-tRNA ligase activity; protein kinase binding activity; and protein kinase inhibitor activity. Predicted to be involved in several processes, including glutaminyl-tRNA aminoacylation; negative regulation of DNA-templated transcription; and negative regulation of signal transduction. Predicted to be located in cytoplasm. Predicted to be part of aminoacyl-tRNA synthetase multienzyme complex. Predicted to be active in cytosol. Biomarker of sciatic neuropathy. Orthologous to human QARS1 (glutaminyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Qars1 |
| Official Name | glutaminyl-tRNA synthetase 1 [Source:RGD Symbol;Acc:1359448] |
| Ensembl ID | ENSRNOG00000060912 |
| Bio databases IDs | |
| Aliases | glutaminyl-tRNA synthetase 1 |
| Synonyms | 1110018N24Rik, 1200016L19Rik, GLNRS, GLUTAMINYL TRANSSYNTHASE, glutaminyl-tRNA synthetase 1, MSCCA, PRO2195, QARS, RGD1562301, RPI1-A11 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Qars1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase binding
- glutamyl-tRNA synthetase, archaeal and eukaryotic family
- protein kinase inhibitor activity
- glutaminyl-tRNA synthetase
- enzyme
- protein binding
- RNA binding
- tRNA synthetases class I (E and Q), anti-codon binding domain
- tRNA synthetases class I (E and Q), catalytic domain
- Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2
- glutamine-tRNA ligase
- Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1
- nucleotidyl transferase superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- progressive microcephaly with seizures and cerebral and cerebellar atrophy
- microcephaly
- hereditary disorder
- Burkitt lymphoma
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
- autosomal dominant mental retardation type 43
regulates
- MT-TQ
role in cell
- apoptosis
- translation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- Nucleus
- cytosol
- mitochondrial matrix
- nuclear scaffolds
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Qars1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tRNA aminoacylation for protein translation
- negative regulation of transcription, DNA-dependent
- negative regulation of stress-activated MAPK cascade
- brain development
- glutaminyl-tRNA aminoacylation
- negative regulation of protein kinase activity
- negative regulation of apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- mitochondrial matrix
- cytosol
- macromolecular complex
- aminoacyl-tRNA synthetase multienzyme complex
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- ATP binding
- protein binding
- glutamine-tRNA ligase activity
- protein kinase inhibitor activity