Kcnc4 Gene Summary [Rat]
Enables voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential; voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential; and voltage-gated potassium channel activity. Involved in negative regulation of neuronal action potential and nervous system development. Located in several cellular components, including cell surface; neuronal cell body; and synaptic vesicle. Is active in several cellular components, including calyx of Held; glycinergic synapse; and synaptic membrane. Biomarker of sciatic neuropathy and status epilepticus. Orthologous to human KCNC4 (potassium voltage-gated channel subfamily C member 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kcnc4 |
| Official Name | potassium voltage-gated channel subfamily C member 4 [Source:RGD Symbol;Acc:1589169] |
| Ensembl ID | ENSRNOG00000060988 |
| Bio databases IDs | |
| Aliases | potassium voltage-gated channel subfamily C member 4 |
| Synonyms | C1ORF30, HKSHIIIC, Kcr2-4, KSHIIIC, KV3.4, potassium voltage gated channel, Shaw-related subfamily, member 4, potassium voltage-gated channel subfamily C member 4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Kcnc4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- potassium channel
- voltage-gated potassium channel
- Ion transport protein
- Potassium voltage-gated channel
- Broad-Complex, Tramtrack and Bric a brac
- BTB_POZ
- protein binding
- voltage-gated ion channel
- ion channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- rotator cuff injury
- oropharyngeal cancer
- myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
- pain
- tuberculosis
regulates
- neurotransmitter
- K+
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- Cytoplasm
- cell surface
- postsynaptic region
- cellular membrane
- presynaptic membrane
- postsynaptic membrane
- synaptic vesicles
- neuromuscular junctions
- juxtaparanodes
- synapse
- perikaryon
- axons
- dendrites
- axon terminals
- nociceptive nerve fibers
- C fiber
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Kcnc4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- potassium ion transport
- potassium ion transmembrane transport
- protein homooligomerization
- synaptic transmission
- regulation of action potential
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- dendrite membrane
- postsynaptic membrane
- voltage-gated potassium channel complex
- neuronal cell body membrane
- plasma membrane
- axon terminus
Molecular Function
What the gene product does at the molecular level
- voltage-gated potassium channel activity
- protein binding
- delayed rectifier potassium channel activity
- potassium channel activity