KCNC4 Gene Summary [Human]

The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. It generates atypical voltage-dependent transient current that may be important for neuronal excitability. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jul 2010]

Details

Type
Retained Intron
Official Symbol
KCNC4
Official Name
potassium voltage-gated channel subfamily C member 4 [Source:HGNC Symbol;Acc:HGNC:6236]
Ensembl ID
ENSG00000116396
Bio databases IDs NCBI: 3749 Ensembl: ENSG00000116396
Aliases potassium voltage-gated channel subfamily C member 4
Synonyms C1ORF30, HKSHIIIC, Kcr2-4, KSHIIIC, KV3.4, potassium voltage gated channel, Shaw-related subfamily, member 4, potassium voltage-gated channel subfamily C member 4
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KCNC4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • potassium channel
  • voltage-gated potassium channel
  • Ion transport protein
  • Potassium voltage-gated channel
  • Broad-Complex, Tramtrack and Bric a brac
  • BTB_POZ
  • protein binding
  • voltage-gated ion channel
  • ion channel

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • Alzheimer disease
  • rotator cuff injury
  • oropharyngeal cancer
  • myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
  • pain
  • tuberculosis
regulated by
  • IL1B
  • Sn50 peptide
  • APP
  • levodopa
  • 3-deazaneplanocin
  • CREB1
  • Influenza A virus (A/Japan/305/57(H2N2))
  • HTT
  • PRKCE
  • Bds2
regulates
  • neurotransmitter
  • K+

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • glutaminergic synapse
  • Cytoplasm
  • cell surface
  • postsynaptic region
  • cellular membrane
  • presynaptic membrane
  • postsynaptic membrane
  • synaptic vesicles
  • neuromuscular junctions
  • juxtaparanodes
  • synapse
  • perikaryon
  • axons
  • dendrites
  • axon terminals
  • nociceptive nerve fibers
  • C fiber

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human KCNC4 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • potassium ion transport
  • potassium ion transmembrane transport
  • protein homooligomerization
  • synaptic transmission
  • regulation of action potential

Cellular Component

Where in the cell the gene product is active
  • presynaptic membrane
  • dendrite membrane
  • postsynaptic membrane
  • voltage-gated potassium channel complex
  • neuronal cell body membrane
  • plasma membrane
  • axon terminus

Molecular Function

What the gene product does at the molecular level
  • voltage-gated potassium channel activity
  • protein binding
  • delayed rectifier potassium channel activity
  • potassium channel activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.