Zbtb10 Gene Summary [Rat]
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in chromosome, telomeric region and nucleoplasm. Predicted to be active in nucleus. Orthologous to human ZBTB10 (zinc finger and BTB domain containing 10). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zbtb10 |
| Official Name | zinc finger and BTB domain containing 10 [Source:RGD Symbol;Acc:708377] |
| Ensembl ID | ENSRNOG00000061862 |
| Bio databases IDs | |
| Aliases | zinc finger and BTB domain containing 10 |
| Synonyms | 4832414A18, ania-11, RINZF, RINZFC, zinc finger and BTB domain containing 10 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Zbtb10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- transcription regulator
- nucleic acid binding
- C2H2-type zinc-finger domain
- BTB_POZ
- protein binding
- sequence-specific DNA binding
- telomeric DNA binding
- C2H2-type zinc finger
- DNA binding
- zinc finger
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- double-stranded DNA binding
- Broad-Complex, Tramtrack and Bric a brac
- Zinc-finger double domain
- BTB/POZ domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- hypertension
- hypothyroidism
- skin neoplasm
- skin neoplasia
- mature T-cell neoplasia
- T-cell non-Hodgkin disease
- non-melanoma skin cancer
- epithelial basal cell carcinoma
- metabolic syndrome X
role in cell
- expression in
- cell cycle progression
- transactivation in
- differentiation
- Gap 0-Gap 1 phase
- JG-231 sensitivity
- imatinib sensitivity
- pravastatin sensitivity
- S phase
- vorinostat sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- telomeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Zbtb10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromosome, telomeric region
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- telomeric DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription