TNFRSF21 Gene Summary [Human]
This gene encodes a member of the tumor necrosis factor receptor superfamily. The encoded protein activates nuclear factor kappa-B and mitogen-activated protein kinase 8 (also called c-Jun N-terminal kinase 1), and induces cell apoptosis. Through its death domain, the encoded receptor interacts with tumor necrosis factor receptor type 1-associated death domain (TRADD) protein, which is known to mediate signal transduction of tumor necrosis factor receptors. Knockout studies in mice suggest that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation. [provided by RefSeq, Jul 2013]
Details
| Type | Protein Coding |
| Official Symbol | TNFRSF21 |
| Official Name | TNF receptor superfamily member 21 [Source:HGNC Symbol;Acc:HGNC:13469] |
| Ensembl ID | ENSG00000146072 |
| Bio databases IDs | |
| Aliases | TNF receptor superfamily member 21, death receptor 6 |
| Synonyms | BM-018, CD358, DR6, TNF receptor superfamily member 21, TR7, tumor necrosis factor receptor superfamily, member 21, tumour necrosis factor receptor superfamily, member 21 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TNFRSF21 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Death domain
- TNFR/NGFR cysteine-rich region
- protein binding
- Tumor necrosis factor receptor superfamily (TNFRSF)
- Death Domain Superfamily of protein-protein interaction domains
- transmembrane receptor
Pathways
Biological processes and signaling networks where the TNFRSF21 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- epithelial thyroid cancer
- hyperplasia
- experimental autoimmune encephalomyelitis
- rheumatoid arthritis
- lung adenocarcinoma
- lung adenocarcinoma formation
- bleeding
- nasal type extranodal NK-/T-cell lymphoma
- mature T-cell neoplasia
role in cell
- proliferation
- expression in
- apoptosis
- cell death
- function
- number
- density
- growth
- maturation
- necroptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TNFRSF21 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of interleukin-10 production
- regulation of oligodendrocyte differentiation
- adaptive immune response
- myelination
- oligodendrocyte apoptotic process
- B cell apoptotic process
- axonal fasciculation
- negative regulation of interleukin-5 production
- negative regulation of B cell proliferation
- negative regulation of T cell proliferation
- apoptotic process
- humoral immune response
- negative regulation of interleukin-13 production
- cellular response to tumor necrosis factor
- T cell receptor signaling pathway
- negative regulation of myelination
- neuron apoptotic process
Cellular Component
Where in the cell the gene product is active
- axon
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding