RAC3 Gene Summary [Human]
The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Details
| Type | Protein Coding |
| Official Symbol | RAC3 |
| Official Name | Rac family small GTPase 3 [Source:HGNC Symbol;Acc:HGNC:9803] |
| Ensembl ID | ENSG00000169750 |
| Bio databases IDs | |
| Aliases | Rac family small GTPase 3 |
| Synonyms | Rac1B, Rac family small GTPase 3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RAC3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium-dependent protein binding
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- GTPase
- enzyme
- protein binding
- basic helix loop helix/Per Arnt Sim domain
- Ras subfamily of RAS small GTPases
- receptor binding domain
- small GTP-binding protein domain
- Rab subfamily of small GTPases
- helix-loop-helix domain
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the RAC3 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Actin Nucleation by ARP-WASP Complex
- Agrin Interactions at Neuromuscular Junction
- Apelin Adipocyte Signaling Pathway
- CXCR4 Signaling
- Endocannabinoid Developing Neuron Pathway
- Ephrin B Signaling
- Ephrin Receptor Signaling
- Fc Epsilon RI Signaling
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- fMLP Signaling in Neutrophils
- Glioblastoma Multiforme Signaling
- Glioma Invasiveness Signaling
- HIF1α Signaling
- Molecular Mechanisms of Cancer
- Netrin Signaling
- Phagosome Maturation
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- PTEN Signaling
- Regulation of Actin-based Motility by Rho
- Semaphorin Signaling in Neurons
- Thrombin Signaling
- Virus Entry via Endocytic Pathways
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- neurodevelopmental disorder with structural brain anomalies and dysmorphic facies
- endometrial cancer
- major depression
- dextran sodium sulfate-induced colitis
- lung adenocarcinoma
- lung adenocarcinoma formation
- epilepsy
- survival
role in cell
- proliferation
- differentiation
- cell death
- degradation in
- apoptosis
- growth
- invasion
- binding
- quantity
- maturation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- glutaminergic synapse
- endomembrane system
- cilia
- cell periphery
- perinuclear region
- postsynaptic region
- cellular membrane
- Nucleus
- Plasma Membrane
- actin filaments
- cytosol
- endoplasmic reticulum membrane
- growth cone
- neurites
- membrane rafts
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RAC3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- Rac protein signal transduction
- motor axon guidance
- cell projection assembly
- establishment or maintenance of cell polarity
- regulation of neuron maturation
- actin filament organization
- positive regulation of substrate adhesion-dependent cell spreading
- respiratory burst
- engulfment of apoptotic cell
- cerebral cortex GABAergic interneuron development
- cell chemotaxis
- cortical cytoskeleton organization
- regulation of actin cytoskeleton organization
- homeostasis of number of cells within a tissue
- Wnt receptor signaling pathway
- positive regulation of cell adhesion mediated by integrin
- synaptic transmission, GABAergic
- actin cytoskeleton organization
- neuromuscular process controlling balance
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- neuronal cell body
- neuron projection
- plasma membrane
- growth cone
- endoplasmic reticulum membrane
- extracellular vesicular exosome
- cytoskeleton
- perinuclear region of cytoplasm
- NADPH oxidase complex
- cytosol
- endomembrane system
- cytoplasmic vesicle
- filamentous actin
- lamellipodium
- cell periphery
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein kinase binding
- protein binding
- GTPase activity
- small monomeric GTPase activity
- calcium-dependent protein binding