TNFSF15 Gene Summary [Human]
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
Details
| Type | Protein Coding |
| Official Symbol | TNFSF15 |
| Official Name | TNF superfamily member 15 [Source:HGNC Symbol;Acc:HGNC:11931] |
| Ensembl ID | ENSG00000181634 |
| Bio databases IDs | |
| Aliases | TNF superfamily member 15, vascular endothelial cell growth inhibitor, TNF superfamily ligand TL1A, TNF ligand-related molecule 1, vascular endothelial growth inhibitor-192A |
| Synonyms | TL1, TL1A, TNF superfamily member 15, TNLG1B, tumor necrosis factor (ligand) superfamily, member 15, tumour necrosis factor (ligand) superfamily, member 15, VEGI, VEGI192A |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TNFSF15 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- death receptor binding
- TNF homology domain
- TNF
- protein binding
- receptor binding
- cytokine
Pathways
Biological processes and signaling networks where the TNFSF15 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- primary biliary cirrhosis
- hyperplasia
- collagen-induced arthritis
- inflammatory bowel disease
- sarcoidosis
- aortic atherosclerosis
- ulcerative colitis
- systemic lupus erythematosus
- leprosy
- asthma
role in cell
- survival
- apoptosis
- production in
- differentiation
- cell death
- proliferation
- expression in
- migration
- phosphorylation in
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- membrane surface
- cellular membrane
- Nucleus
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TNFSF15 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- immune response
- signal transduction
- activation of NF-kappaB-inducing kinase activity
- activation of cysteine-type endopeptidase activity involved in apoptotic process
Cellular Component
Where in the cell the gene product is active
- extracellular space
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- tumor necrosis factor receptor binding
- cytokine activity
- receptor binding