RHOJ Gene Summary [Human]
This gene encodes one of the many small GTP-binding proteins in the Rho family shown to be associated with focal adhesions in endothelial cells (PMID: 21148427, 22103495). The encoded protein is activated by vascular endothelial growth factor and may regulate angiogenesis. [provided by RefSeq, Dec 2011]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | RHOJ |
| Official Name | ras homolog family member J [Source:HGNC Symbol;Acc:HGNC:688] |
| Ensembl ID | ENSG00000126785 |
| Bio databases IDs | |
| Aliases | ras homolog family member J |
| Synonyms | 1110005O19Rik, ARHJ, ras homolog family member J, RASL7B, TC10B, Tc10 beta, TC10L, Tc10-like, TC10-LIKE RHO GTPASE, Tc10 β, TCL |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RHOJ often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTP binding
- small GTP-binding protein domain
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- Rab subfamily of small GTPases
- GTPase
- enzyme
- protein binding
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
- Ras subfamily of RAS small GTPases
Pathways
Biological processes and signaling networks where the RHOJ gene in human plays a role, providing insight into its function and relevance in health or disease.
- Actin Nucleation by ARP-WASP Complex
- Cholecystokinin/Gastrin-mediated Signaling
- CXCR4 Signaling
- Germ Cell-Sertoli Cell Junction Signaling
- Glioblastoma Multiforme Signaling
- Glioma Invasiveness Signaling
- Gαq Signaling
- HMGB1 Signaling
- IL-8 Signaling
- ILK Signaling
- Integrin Signaling
- mTOR Signaling
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- Regulation of Actin-based Motility by Rho
- RhoGDI Signaling
- Semaphorin Signaling in Neurons
- Serotonin Receptor Signaling
- Signaling by Rho Family GTPases
- Sphingosine-1-phosphate Signaling
- Tec Kinase Signaling
- Thrombin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obsessive-compulsive disorder
- androgenic alopecia
- streptozotocin induced type1 diabetes
- oral squamous cell carcinoma
- squamous cell cancer of the oral cavity
role in cell
- molecular cleavage in
- proliferation
- quantity
- phosphorylation in
- apoptosis
- organization
- survival
- migration by
- internalization by
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- plasma membrane fraction
- nuclear fraction
- Plasma Membrane
- vesicles
- early endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RHOJ gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- retina vasculature morphogenesis in camera-type eye
- regulation of endothelial cell migration
- angiogenesis
- establishment or maintenance of cell polarity
- actin filament organization
- Cdc42 protein signal transduction
- positive regulation of cell migration involved in sprouting angiogenesis
- endocytosis
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein kinase binding
- protein binding
- GTPase activity