Ndufa6 Gene Summary [Rat]
Predicted to be involved in mitochondrial respiratory chain complex I assembly. Predicted to be located in mitochondrial membrane. Predicted to be part of respiratory chain complex I. Predicted to be active in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 33. Orthologous to human NDUFA6 (NADH:ubiquinone oxidoreductase subunit A6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ndufa6 |
| Official Name | NADH:ubiquinone oxidoreductase subunit A6 [Source:RGD Symbol;Acc:1309818] |
| Ensembl ID | ENSRNOG00000008569 |
| Bio databases IDs | |
| Aliases | NADH:ubiquinone oxidoreductase subunit A6 |
| Synonyms | 2700038D15Rik, B14, B230217P19Rik, CI-B14, LYRM6, MC1DN33, NADHB14, NADH DEHYDROGENASE 1 alpha, NADH DEHYDROGENASE 1 α, NADH:ubiquinone oxidoreductase subunit A6 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ndufa6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Complex 1 protein (LYR family)
- enzyme
- NADH2 dehydrogenase (ubiquinone)
- LYR (leucine-tyrosine-arginine) motif found in Complex1_LYR-like superfamily
Pathways
Biological processes and signaling networks where the Ndufa6 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- Huntington disease
- nuclear type 33 mitochondrial complex I deficiency
- chronic kidney disease
- mitochondrial disorder
- hereditary disorder
- insulin resistance
- productive infection by HIV-1
regulates
- Mitochondrial ETC 1
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial membrane
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ndufa6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to oxidative stress
- transmembrane transport
- mitochondrial electron transport, NADH to ubiquinone
- mitochondrial respiratory chain complex I assembly
- aerobic respiration
- mitochondrial ATP synthesis coupled proton transport
Cellular Component
Where in the cell the gene product is active
- mitochondrial membrane
- respiratory chain complex I
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- NADH dehydrogenase (ubiquinone) activity